@thesis{thesis,
		author={Nur  Fitriana},
		title ={OPTIMASI PENGGUNAAN PATI SINGKONG PREGELATINASI-AVICEL
PH 101 SEBAGAI BAHAN PENGHANCUR PADA FORMULA TABLET
EKSTRAK BUNGA ROSELLA (Hibiscus sabdariffa L.)},
		year={2020},
		url={http://librepo.stikesnas.ac.id/414/},
		abstract={Rosella flowers (Hibiscuss sabdariffa L.) in traditional medicine can be efficacious
to provide protection against various diseases, such as coronary heart disease, cancer, lowering
cholesterol, liver disorders. The combination of Avicel PH 101 and pregelatinized cassava
starch as a disentegran. The use of pregelatinized cassava starch as a disintegran is to increase
particle size so that a larger particle size is obtained, so that when contact with water will be
more easily destroyed Optimization with the simplex lattice design method aims to facilitate
the design, compile data mathematically. Rosella flower extract was obtained by maceration of
rosella flower powder using 70% ethanol. Optimization of tablets based on the Simplex Lattice
Design method using Design Expert software version 10 and verified using one sample t-test.
The results showed that rosella flower extracts were prepared by tablets with a wet granulation
method with a mixture of Avicel PH 101 and pregelatinized cassava starch, formula with
comparison 6.5%: 3.4% as the optimum formula with the results of weight uniformity test 0,54
± 0,01, hardness 5,25 ± 0,60 kg, fragility 0,45 ± 0,32%, disintegration time 11.56 ± 0.05
minutes and size uniformity of 0,43 ± 0,01 %}
		}