@thesis{thesis,
		author={Viqi  Kurnia Wardani},
		title ={FORMULASI TRANSDERMAL PATCH
EKSTRAK ETANOL BIJI PEPAYA (Carica papaya L.)
DENGAN BASIS HYDROXYPROPIL METILCELLULOSE
(HPMC)},
		year={2020},
		url={http://librepo.stikesnas.ac.id/481/},
		abstract={Papaya seeds contain secondary metabolites such as flavonoids, that are
antioxidants. Ethanolic extract of Papaya seed (Carica papaya L.) was
formulated into transdermal patch to avoid the fisrt pass effect and maintain the
bioavailability of drugs in plasma besides that flavonoids have low solubility
sothat transdermal patches are made to increase their bioavailability. This
research aims to determine the concentration of HPMC which can produce a
good physical stability, and to find out the differenceson physical stability of the
transdermal patch. Papaya seeds were extracted using maceration method with
95% ethanol. It is made into transdermal patch with 1%, 2%, 3% concentration of
polymer HPMC. There are some testing include organoleptic, uniformity of
weight, drying shrinkage, thickness, moisture uptake, folding endurance and pH.
The result of this research showedthat adding HPMC has impacts on increasing
weight, thickness, folding endurance, and moisture uptake. Transdermal patch
with 1% HPMC concentration has better stability than other formulas with a
weight of approximately 0,27 g, a thickness of 0,01 mm, loss drying 0%, and
moisture uptake12,01%}
		}