@thesis{thesis,
		author={Fatkhi  Rizky Kurniawan},
		title ={PENGARUH PEMBENTUKAN NANO-PARTIKEL TERHADAP
KARAKTERISTIK KOLAGEN YANG DIISOLASI SECARA
ENZIMATIK DARI SISIK IKAN NILA (Oreochromis niloticus)},
		year={2021},
		url={http://librepo.stikesnas.ac.id/791/},
		abstract={The need for collagen continues to increase because humans cannot produce
collagen starting at the age of 40 years. Tilapia fish scales can be used as an
alternative material for collagen because it has not been processed optimally, but it
can produce 0.63% collagen with acid solvents, according to Hartati (2010)
enzymes can be used as collagen solvents with the advantage of producing more
yield. The development of pharmaceutical technology demands the formation of
nano-collagen that shows a therapeutic effect more quickly (Pringgadani, 2018).
Collagen extraction from tilapia (Oreochromis niloticus) scales was
enzymatically carried out with papain enzyme as solvent, the particle size reduction
method used was a magnetic stirrer. Collagen and nano-collagen were compared
with their physical and chemical test results to determine the effect of particle size
reduction treatment.
Extraction of tilapia (Oreochromis niloticus) scales using papain enzyme
resulted in a yield of 31.2 g. The treatment of nano-particles on yield did not show
a significant effect on the water content test, ash content test, protein content test,
and fat content test, but gave an effect on physical properties on organoleptic tests
and acidity tests. The yield from the extraction met the standards for determining
the degree of acidity and water content, while the yield with the treatment of nanoparticles met the standards for determining the water content.}
		}