@thesis{thesis,
		author={Erna  Kurniasari},
		title ={FORMULASI SEDIAAN TABLET EFFERVESCENT
EKSTRAK DAUN KEMANGI (Ocimum basilicum L.) SEBAGAI
DESINFEKTAN ALAMI},
		year={2022},
		url={http://librepo.stikesnas.ac.id/862/},
		abstract={Basil leaves (Ocimum basilicum L.) is a plant that has antibacterial activity
against Staphylococcus aureus. The content of compounds that act as antibacterial
is one of them flavonoids. Effervescent tablets are tablet preparations when put in
water a chemical reaction will occur between acid and sodium bicarbonate to
produce carbon dioxide gas (COâ‚‚) and water. The advantage of effervescent
tablets as a desinfectant of basil leaf extract (Ocimum basilicum L.) is as an effort
to control sanitation on the surface of inanimate objects. The purpose of this study
was to determine the activity of effervescent tablets from basil leaf extract
(Ocimum basilicum L.) as antibacterial against Staphylococcus aureus and to
determine the effect of variations in the best concentration of PVP as a binder
with concentrations of 0.5%, 1%, and 1.5%. Effervescent tablets were made with
a concentration of 45% basil leaf extract and 0.5%, 1%, and 1.5% PVP
concentrations. The formulations were tested for physical properties of granules
and effervescent tablets including the results of flow time test, angle of repose test,
moisture content test, organoleptic test, pH test, weight uniformity test, size
uniformity test, friability test, tablet hardness test, and tablet dissolving time test,
and antibacterial activity test using disc diffusion method. The test data obtained
were analyzed by One Way Anova with a 95% confidence level. The results
showed that there was an effect of variations in polyvinylpyrrolidone (PVP) on
the physical properties of effervescent tablets with basil leaf extract (Ocimum
basilicum L.) as a desinfectant. PVP is 1.5%. Increasing the concentration of PVP
in effervescent tablets did not affect the diameter of the bacterial inhibitory power.
The bacterial activity test of the third formula containing basil leaf extract resulted
in a moderate inhibition zone, namely the average diameter of the inhibition zone
was 7.28 mm ± 0.069.}
		}