@thesis{thesis, author={Diaz Ayu Tifany}, title ={FORMULASI SEDIAAN GEL ANTISEPTIK EKSTRAK ETANOL DAUN PEPAYA (Carica papaya L.) DAN UJI EFEKTIVITAS DENGAN METODE REPLIKA}, year={2022}, url={http://librepo.stikesnas.ac.id/930/}, abstract={Papaya leaves contain chemical compounds that are antiseptic, antifungal, and antibacterial. Gel has advantages compared to other preparations, namely the gel has a good spreading ability on the skin, provides a cooling effect, does not inhibit physiological hair growth, is easily washed with water and has good drug release ability. The purpose of this study was to determine at what concentration the ethanol extract of papaya leaves (Carica papaya L) in order to produce a good antiseptic gel of papaya leaf ethanol extract (Carica papaya L), and to find out at what concentration of papaya leaf ethanol extract (Carica papaya L) which produces the best physical properties in the antiseptic gel preparation of papaya leaf ethanol extract (Carica papaya L). In this study, the independent variable was used, namely the difference in the concentration of the papaya leaf ethanol extract, namely 5%, 10% and 15%. Test the effectiveness of the antiseptic gel ethanol extract of papaya leaves (Carica papaya L) using the replica method to determine the amount of colony growth and the data were analyzed using One Way ANOVA. In this study, the good physical properties of the gel were shown in FIII with a concentration of 15%. In FIII, the results obtained a homogeneous gel, thick green with a distinctive papaya leaf aroma, with a pH of 6, the results obtained were 600 dPa's viscosity, 8.14±0.14cm spreadability, 12.00±0.44 second adhesion, and 87 effectiveness test results. 67±37.85 colonies. The results of the One Way ANOVA test on the effectiveness of the papaya leaf ethanol extract gel obtained the results of 0.005 < (0.05), indicating that there was a significant difference in the number of colonies. The higher the concentration of the papaya leaf ethanol extract used, the lower the number of bacterial colonies} }