@thesis{thesis,
		author={ },
		title ={Variasi Genetik IL-10 (-1082 G/A) pada Orang dengan Skizofrenia Suku Batak},
		year={2022},
		url={},
		abstract={Background: Schizophrenia as a multifaceted disorder is characterized by persistent psychosis and gradual cognitive decline over the course of the disorder. Underlying mechanism of schizophrenia has been linked to immune dysregulation in central nervous system. IL-10 is one of anti-inflammatory cytokines in which its secretion is regulated by genetic variation. Thus, we aim to investigate allelic and genotypic variation of IL-10 gene in Bataknese with schizophrenia compared to healthy control.
Method: This study is a comparative observational study with a case-control design. Blood samples were taken from a total of 194 subjects (n = 97 for each case and control group), then identified the IL-10 allele and genotype (-1082 G/A) using the Polymerase Chain Reaction- Restriction Fragment Length Polymorphism (PCR-RFLP).
Result: The difference in the proportion of sex was found to be statistically significant (p = 0.008), in which male was more often found in the case group. The mean age in the case group was 34.27 + 6.85, and were more likely to be unemployed and did not attend higher education (p = 0.001). Identification of allele variation showed that the dominant allele in the Batak tribe was allele A (91.6% in ODS, and 81.0% in control). The proportion of AA genotypes in ODS was 84.5% and in controls was 81.0%. Homozygous GG genotypes were not found in either group. Individuals with the A allele and the AA genotype were more common in the ODS group (p = 0.018 and 0.011, respectively). Individuals with the A allele had a 2.26-fold higher risk of developing schizophrenia (OR = 2.26, 95% CI = 1.1825 ? 4.3559) and individuals with the AA genotype also had a 2.56 times higher risk of developing schizophrenia ( OR = 2.56, 95% CI = 1.280 ? 5.152). There was no difference in onset based on genotypic variation (p = 1.00).
Conclusion: Allelic and genotypic variation of the IL-10 (-1082 G/A) was found between Bataknese with schizophrenia and healthy control. A allele and AA genotype serve as contributing risk factor of developing schizophrenia.}
		}