EFEKTIVITAS ANTIPIRETIK FILTRAT DAUN SELASIH (Ocimum sanctum
L) TERHADAP PENURUNAN SUHU TUBUH TIKUS PUTIH JANTAN
(Rattus norvegicus) YANG DIDEMAMKAN DENGAN VAKSIN DPT
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Institusion
Universitas Muhammadiyah Malang
Author
SAKINAH WATTY, IKA
Subject
Q Science (General)
Datestamp
2012-06-29 08:05:46
Abstract :
Fever is the body reaction toward disease and marked with increasing of body temperature above normal condition and fever cause by increasing of body temperature central regulator in hypothalamus affected by IL-1 temperature regulator when we are in healthy condition. Fever happen due to the body expose toward microorganism infection (virus, bacteria, parasite) and may cause by non infection factor such as dehydration, allergic, stress, trauma, cancer, tirotoxicosity and others. Fever often occurs together with headache, declining appetite, limp, muscle pain, dehydration and seizure. Selasih leaf contain eugenol functioning as anti pyretic, because eugenol activity could inhibit the forming of prostaglandin. This experiment has the objective to found out the effect of selasih leaf filtrate toward the decreasing body temperature of male white mice and also to found out the most effective dose of selasih leaf filtrate used toward the decreasing body temperature of male white mice. The type of the experiment is real experiment, population in this experiment is male white mice (Rattus norvegicus) with amount of sample is 24 consist of 6 different treatment group and each repeated 4 times. Sample obtained technique is using Simple Random Sampling. The experiment variables comprise of free variables with dose of selasih leaf filtrate, and the bound variables with the decreasing body temperature on mice, while the control variables is mice’s sex, mice’s age, mice’s weight, DPT vaccine dose, the condition of mice’s cage, type of food and drinks. Experiment design using Complete Block Random Design. Data analysis is using ANOVA and Duncan Test. According to one way variance analysis result, it is gain calculated F value > table F value in significant rate of 1% which means there is effect of selasih leaf filtrate anti pyretic toward the decreasing of body temperature on male white mice by viewing the amount of decrease body temperature observed 4 hours after fever. From the 1% Duncan test, the most effective dose showed in this experiment toward the decreasing of body temperature on mice is F group (selasih leaf filtrate dose 2,5 ml/gr BB) and this result is not significantly different for result obtained in B group (Paracetamol 0,2 ml/gr BB).
Fever is the body reaction toward disease and marked with increasing of body temperature above normal condition and fever cause by increasing of body temperature central regulator in hypothalamus affected by IL-1 temperature regulator when we are in healthy condition. Fever happen due to the body expose toward microorganism infection (virus, bacteria, parasite) and may cause by non infection factor such as dehydration, allergic, stress, trauma, cancer, tirotoxicosity and others. Fever often occurs together with headache, declining appetite, limp, muscle pain, dehydration and seizure. Selasih leaf contain eugenol functioning as anti pyretic, because eugenol activity could inhibit the forming of prostaglandin. This experiment has the objective to found out the effect of selasih leaf filtrate toward the decreasing body temperature of male white mice and also to found out the most effective dose of selasih leaf filtrate used toward the decreasing body temperature of male white mice. The type of the experiment is real experiment, population in this experiment is male white mice (Rattus norvegicus) with amount of sample is 24 consist of 6 different treatment group and each repeated 4 times. Sample obtained technique is using Simple Random Sampling. The experiment variables comprise of free variables with dose of selasih leaf filtrate, and the bound variables with the decreasing body temperature on mice, while the control variables is mice’s sex, mice’s age, mice’s weight, DPT vaccine dose, the condition of mice’s cage, type of food and drinks. Experiment design using Complete Block Random Design. Data analysis is using ANOVA and Duncan Test. According to one way variance analysis result, it is gain calculated F value > table F value in significant rate of 1% which means there is effect of selasih leaf filtrate anti pyretic toward the decreasing of body temperature on male white mice by viewing the amount of decrease body temperature observed 4 hours after fever. From the 1% Duncan test, the most effective dose showed in this experiment toward the decreasing of body temperature on mice is F group (selasih leaf filtrate dose 2,5 ml/gr BB) and this result is not significantly different for result obtained in B group (Paracetamol 0,2 ml/gr BB).
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