PENGARUH PAPARAN ASAP ROKOK ELEKTRONIK (e-cigarette) DAN KONVENSIONAL TERHADAP JUMLAH SEL GOBLET PADA GAMBARAN HISTOLOGI TRAKEA TIKUS PUTIH JANTAN (Rattus norvegicus strain wistar)
Total View This Week7
Total View This Week7
Institusion
Universitas Muhammadiyah Malang
Author
Kharimah, Yusrotun
Subject
R Medicine (General)
Datestamp
2020-01-03 07:37:39
Abstract :
Background: : The number of electronic smokers increased from 0.3% in 2011 to 2.5% in 2015. Previous studies have shown that there are harmful substances in e-cigarette which also found in the conventional ones. This leads to the increasing amount of goblet cells in the trachea.Objective:Finding the effect of e-cigarette and conventional cigarette to the amount of goblet cells in the trachea in male white rats (Rattus norvegicus strain wistar).Methods: Experimental research with post test control only group design. 16 rats were divided into 4 groups: normal group, conventional cigarettes with 2.3 mg nicotine, e-cigarettes with 3 mg nicotine, and e-cigaretteswith 0 mg nicotine. The trachea was taken to provide histologic preparation with HE staining and observed with light microscope (400x). Data was analysed using One-way ANOVA and Post-Hoc test.Resultsand discussion:One-way ANOVA test showed significant difference (p = 0,000) among groups, the Post-Hoc test showed significant differences (p = 0,000) between normal group and all treatment groups and there was no significant differences among treatment groups (p = 1,000).This is because the toxic materials such as carbonmonoxide, propylene glycol, formaldehyde, nitrosamine, and other carcinogenic materials.Conclusions:Smoke exposure of electronic cigarette (e-cigarette) and conventional cigarettes have the same effect on increasing the amount of goblet cells in the rats trachea.
Background: : The number of electronic smokers increased from 0.3% in 2011 to 2.5% in 2015. Previous studies have shown that there are harmful substances in e-cigarette which also found in the conventional ones. This leads to the increasing amount of goblet cells in the trachea.Objective:Finding the effect of e-cigarette and conventional cigarette to the amount of goblet cells in the trachea in male white rats (Rattus norvegicus strain wistar).Methods: Experimental research with post test control only group design. 16 rats were divided into 4 groups: normal group, conventional cigarettes with 2.3 mg nicotine, e-cigarettes with 3 mg nicotine, and e-cigaretteswith 0 mg nicotine. The trachea was taken to provide histologic preparation with HE staining and observed with light microscope (400x). Data was analysed using One-way ANOVA and Post-Hoc test.Resultsand discussion:One-way ANOVA test showed significant difference (p = 0,000) among groups, the Post-Hoc test showed significant differences (p = 0,000) between normal group and all treatment groups and there was no significant differences among treatment groups (p = 1,000).This is because the toxic materials such as carbonmonoxide, propylene glycol, formaldehyde, nitrosamine, and other carcinogenic materials.Conclusions:Smoke exposure of electronic cigarette (e-cigarette) and conventional cigarettes have the same effect on increasing the amount of goblet cells in the rats trachea.
Download
book
BibTex
Latex, Jabref
cloud_download
Original Resource
url resource Institution
