UJI AKTIVITAS EKSTRAK DAUN KARET KERBAU (Ficus elastica Roxb.
Ex Hornem) SEBAGAI ANTI HIPERKOLESTEROLEMIA PADA TIKUS
PUTIH JANTAN (Rattus norvegicus) GALUR SPRAGUE DAWLEY
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Institusion
Universitas Pakuan
Author
Afridah Nasution, Meri
Moerfiah
Ramani, Sofyan
Moerfiah
Ramani, Sofyan
Subject
Biologi
Datestamp
2022-09-03 18:01:40
Abstract :
ABSTRACT Hypercholesterolemia is a major risk factor for the development of atherosclerosis. To be able to lower total cholesterol levels, anti hypercholesterolemia is needed. One of the plants that can lower cholesterol levels in the blood is buffalo rubber leaves (Ficus elastica Roxb. Ex Hornem) because they contain flavonoids and steroids. The purpose of this study was to determine the activity and use of buffalo rubber leaf extract dosages which are effective as anti hypercholesterolemia, using a Factorial Factor Random Block Design. This is the dose of P1(100mg / KgBB); P2 (200mg / KgBB); P3 (300 mg / KgBB) negative control (K-) and positive control (K +) with 5 repetitions. The results showed that giving buffalo rubber leaf extract could reduce total cholesterol levels, so that it has anti hypercholesterolemic activity in male white rats. The optimum interaction between dosage and length of time for giving buffalo rubber leaf extract as anti hypercholesterolemia is a dosage of 300mg / KgBW with a duration of 15 days. Keywords: Hypercholesterolemia, Buffalo Rubber, Male White Rats
ABSTRACT Hypercholesterolemia is a major risk factor for the development of atherosclerosis. To be able to lower total cholesterol levels, anti hypercholesterolemia is needed. One of the plants that can lower cholesterol levels in the blood is buffalo rubber leaves (Ficus elastica Roxb. Ex Hornem) because they contain flavonoids and steroids. The purpose of this study was to determine the activity and use of buffalo rubber leaf extract dosages which are effective as anti hypercholesterolemia, using a Factorial Factor Random Block Design. This is the dose of P1(100mg / KgBB); P2 (200mg / KgBB); P3 (300 mg / KgBB) negative control (K-) and positive control (K +) with 5 repetitions. The results showed that giving buffalo rubber leaf extract could reduce total cholesterol levels, so that it has anti hypercholesterolemic activity in male white rats. The optimum interaction between dosage and length of time for giving buffalo rubber leaf extract as anti hypercholesterolemia is a dosage of 300mg / KgBW with a duration of 15 days. Keywords: Hypercholesterolemia, Buffalo Rubber, Male White Rats
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