UJI AKTIVITAS ANTIKOLESTEROL EKSTRAK KECIPIR
(Psophocarpus tetragonolobus L.) SECARA IN VITRO
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Dania, Rizki Arsita Kusumaningrum
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2020-12-23 02:59:36
Abstract :
A daily food containing fat and an unhealthy lifestyle results in an increase in blood cholesterol levels. High cholesterol levels lead to athericlerosis and become a cause of stroke and heart disease and other diseases. Plants winged bean(Psophocarpus tetragonolobus L.) which has the content of flavonoids and phenolic compounds allegedly efficacious to lower cholesterol in the blood. This study aims to determine anticholesterol activity extract of winged in vitro and to know at concentration how much extract of winged bee reach EC50 (Effective Concentration). The extraction method used is a maceration method using 70% ethanol solvent. Cholesterol concentration analysis was performed using Lieberman-Burchard method. The ethanol extract of winged bean is made series of concentration 50 ppm, 100 ppm, 150 ppm, 200 ppm and 250 ppm. The results showed the percentage of decrease in cholesterol levels after administration of ethanol extract of 37.8%, respectively; 44.11%; 52.55%; 59.25%; and 66.90%. EC50 was achieved at a concentration of 135,69 ppm.
A daily food containing fat and an unhealthy lifestyle results in an increase in blood cholesterol levels. High cholesterol levels lead to athericlerosis and become a cause of stroke and heart disease and other diseases. Plants winged bean(Psophocarpus tetragonolobus L.) which has the content of flavonoids and phenolic compounds allegedly efficacious to lower cholesterol in the blood. This study aims to determine anticholesterol activity extract of winged in vitro and to know at concentration how much extract of winged bee reach EC50 (Effective Concentration). The extraction method used is a maceration method using 70% ethanol solvent. Cholesterol concentration analysis was performed using Lieberman-Burchard method. The ethanol extract of winged bean is made series of concentration 50 ppm, 100 ppm, 150 ppm, 200 ppm and 250 ppm. The results showed the percentage of decrease in cholesterol levels after administration of ethanol extract of 37.8%, respectively; 44.11%; 52.55%; 59.25%; and 66.90%. EC50 was achieved at a concentration of 135,69 ppm.
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