OPTIMASI ASAM STEARAT DAN TEA PADA FORMULA
SEDIAAN KRIM EKSTRAK KULIT PISANG KEPOK (Musa
paradisiaca L.)
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Romadona, Ayu Safitri
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2020-12-23 02:59:39
Abstract :
The content of banana kepok peel has flavonoid compounds used as antioxidants. The aim of this research is to know the effect of combination of stearic acid and trietanolamin on physical properties and get optimum formula. Cream is made 8 formula with stearic acid 15% minimum concentration and maximum concentration 17%, triethanolamine with minimum concentration 2% and maximum concentration 4% according to optimization Simplex lattice design. The optimization of the formula uses the SLD method with the physical properties parameters of the cream. The optimum cream formula on the combination of stearic acid 16.7 grams and triethanolamine 2.3 grams. Optimal formula compared to prediction results in SLD software for pH got 6.1, viscosity 237.47, adhesion 12.32, power spread 18.11, protection 14.98. which showed no significant difference in the test, then has good acceptability to respondents.
The content of banana kepok peel has flavonoid compounds used as antioxidants. The aim of this research is to know the effect of combination of stearic acid and trietanolamin on physical properties and get optimum formula. Cream is made 8 formula with stearic acid 15% minimum concentration and maximum concentration 17%, triethanolamine with minimum concentration 2% and maximum concentration 4% according to optimization Simplex lattice design. The optimization of the formula uses the SLD method with the physical properties parameters of the cream. The optimum cream formula on the combination of stearic acid 16.7 grams and triethanolamine 2.3 grams. Optimal formula compared to prediction results in SLD software for pH got 6.1, viscosity 237.47, adhesion 12.32, power spread 18.11, protection 14.98. which showed no significant difference in the test, then has good acceptability to respondents.
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