OPTIMASI PROPORSI ASAM STEARAT DAN TRIETANOLAMIN
PADA KRIM EKSTRAK ETANOL BUNGA TELANG (Clitoria ternatea L)
DAN UJI AKTIVITAS ANTIOKSIDAN
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Arvani, Ardyatama Putri
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2020-12-23 06:29:47
Abstract :
Butterfly pea flower (Clitoria ternatea L.) has been studied to contain phenolic and flavanoid chemicals which have antioxidant activity. Butterfly pea flower extract is formulated in a cream dosage form with a combination of the proportions of stearic acid and triethanolamine to produce a cream with more stable physical properties with an oil-in-water emulsion type. This study aims to examine the effect of the proportion of stearic acid and triethanolamine concentrations on the physical properties of cream in order to produce the optimum formula and to determine the antioxidant activity of the cream preparation. Cream preparations are made with a 0.2% concentration of butterfly pea flower extract using stearic acid and triethanolamine as emulsifier. Each formula was prepared and tested for the physical properties of the cream including organoleptic, homogeneity, pH, viscosity, adhesion and dispersibility. The composition of stearic acid and triethanolamine was determined by the Simplex Lattice Design method using Design Expert 12. The experimental results and SLD predictions were validated by one sample t-test with a confidence level of 95%. The optimum formula was tested for antioxidant activity by the FRAP (Ferric Reducing Antioxidant Power) method and analyzed using UV-Vis spectrophotometry at a wavelength of 701 nm using quercetinas a comparison. The optimum formula for butterfly pea flower ethanol extract cream consists of 16.4% stearic acid and 2.6% triethanolamine. The physical properties test results obtained a homogeneous cream with a pH value of 6-7 with a viscosity of 190 and a spreadability of 6.36.The results of the validation of the optimum formula with the one sample t-test on the response of pH, viscosity, and dispersion showed a predictive value >0,05, which means that the data was not significantly different compared to prediction SLD. Based on data analysis, the average value of the antioxidant activity of butterfly pea flower extract (Clitoria ternatea L.) was 9,423±1,265 mgQE / g sample, meaning that each gram of sample contained 9,423±1,265 mgQE which was equivalent to the quercetin standard. This shows that the telang flower extract has antioxidant activity equivalent to quercetin
Butterfly pea flower (Clitoria ternatea L.) has been studied to contain phenolic and flavanoid chemicals which have antioxidant activity. Butterfly pea flower extract is formulated in a cream dosage form with a combination of the proportions of stearic acid and triethanolamine to produce a cream with more stable physical properties with an oil-in-water emulsion type. This study aims to examine the effect of the proportion of stearic acid and triethanolamine concentrations on the physical properties of cream in order to produce the optimum formula and to determine the antioxidant activity of the cream preparation. Cream preparations are made with a 0.2% concentration of butterfly pea flower extract using stearic acid and triethanolamine as emulsifier. Each formula was prepared and tested for the physical properties of the cream including organoleptic, homogeneity, pH, viscosity, adhesion and dispersibility. The composition of stearic acid and triethanolamine was determined by the Simplex Lattice Design method using Design Expert 12. The experimental results and SLD predictions were validated by one sample t-test with a confidence level of 95%. The optimum formula was tested for antioxidant activity by the FRAP (Ferric Reducing Antioxidant Power) method and analyzed using UV-Vis spectrophotometry at a wavelength of 701 nm using quercetinas a comparison. The optimum formula for butterfly pea flower ethanol extract cream consists of 16.4% stearic acid and 2.6% triethanolamine. The physical properties test results obtained a homogeneous cream with a pH value of 6-7 with a viscosity of 190 and a spreadability of 6.36.The results of the validation of the optimum formula with the one sample t-test on the response of pH, viscosity, and dispersion showed a predictive value >0,05, which means that the data was not significantly different compared to prediction SLD. Based on data analysis, the average value of the antioxidant activity of butterfly pea flower extract (Clitoria ternatea L.) was 9,423±1,265 mgQE / g sample, meaning that each gram of sample contained 9,423±1,265 mgQE which was equivalent to the quercetin standard. This shows that the telang flower extract has antioxidant activity equivalent to quercetin
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