OPTIMASI PENGGUNAAN KARBOPOL DAN HPMC SEBAGAI
GELLING AGENT DALAM FORMULASI GEL EKSTRAK
ETANOL BIJI PEPAYA (Carica papaya L.) DAN
UJI AKTIVITAS ANTIOKSIDAN
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Rizki, A. Dwi Lestari
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2020-12-23 06:30:13
Abstract :
Papaya seeds (Carica papaya L.) contain flavonoids, phenols, saponins, and alkaloids that have the potential to act as natural antioxidants. The papaya seed ethanol extract which has antioxidant activity is formulated in the form of a gel dosage. The purpose of making a gel preparation is because it has good drug release and good ability to spread on the skin. In addition, to determine the optimal combination of HPMC and Karbopol concentrations in papaya seed ethanol extract gel which can provide antioxidant activity. In this study, using maceration methods and Simplex Latice Design on the preparation formula to obtain the optimum formula based on the parameters of the pH test, spreadability, adhesion, and viscosity. Verification of the optimal formula used is the statistical test using the one sample t test. In measuring antioxidants using the ABTS method (2,2'-azino-bis (3-ethylbenzothiazolin) -6-sulfonic acid) which is expressed in the form of IC50 values. The results showed that the yield of papaya seed ethanol extract was 17.7%. The optimum formula for the gel preparation contains a papaya seed ethanol extract of 1.6%, based on the Simplex Latice Design method, namely on the basis combination of HPMC 4.96 grams and 0.04 grams Karbopol with a desirability value of 0.952. Based on the pH test value of 5 ± 0.00, the spreadability test of 5.37 ± 0.28, the adhesion test of 2.47 ± 0.13, and the viscosity test of 600 ± 0.00. The test value of each physical characteristic is declared valid. Based on the one sample t test and the results of the optimum cycling test, the formula is stable. The average IC50 value of the antioxidant activity of the papaya seed ethanol extract gel was 34.99 ± 0.065 ppm with a very strong category.
Papaya seeds (Carica papaya L.) contain flavonoids, phenols, saponins, and alkaloids that have the potential to act as natural antioxidants. The papaya seed ethanol extract which has antioxidant activity is formulated in the form of a gel dosage. The purpose of making a gel preparation is because it has good drug release and good ability to spread on the skin. In addition, to determine the optimal combination of HPMC and Karbopol concentrations in papaya seed ethanol extract gel which can provide antioxidant activity. In this study, using maceration methods and Simplex Latice Design on the preparation formula to obtain the optimum formula based on the parameters of the pH test, spreadability, adhesion, and viscosity. Verification of the optimal formula used is the statistical test using the one sample t test. In measuring antioxidants using the ABTS method (2,2'-azino-bis (3-ethylbenzothiazolin) -6-sulfonic acid) which is expressed in the form of IC50 values. The results showed that the yield of papaya seed ethanol extract was 17.7%. The optimum formula for the gel preparation contains a papaya seed ethanol extract of 1.6%, based on the Simplex Latice Design method, namely on the basis combination of HPMC 4.96 grams and 0.04 grams Karbopol with a desirability value of 0.952. Based on the pH test value of 5 ± 0.00, the spreadability test of 5.37 ± 0.28, the adhesion test of 2.47 ± 0.13, and the viscosity test of 600 ± 0.00. The test value of each physical characteristic is declared valid. Based on the one sample t test and the results of the optimum cycling test, the formula is stable. The average IC50 value of the antioxidant activity of the papaya seed ethanol extract gel was 34.99 ± 0.065 ppm with a very strong category.
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