OPTIMASI GEL EKSTRAK ETANOL BUNGA TELANG
(Clitoria ternatea L) DENGAN KOMBINASI HPMC DAN KARBOPOL
BESERTA UJI AKTIVITAS ANTIOKSIDAN
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Arina, Manasikana
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2020-12-23 06:31:26
Abstract :
Butterfly pea flower (Clitoria ternatea L) has been studied to contain phenolic and flavonoid chemicals which have antioxidant activity. Butterfly pea flower extract is formulated in a gel dosage form with a combination of HPMC and carbopol. in order to produce a gel with better physical properties than single use. This study aims to examine the effect of variations in the concentration of HPMC and carbopol on the physical properties of the gel, in order to produce the optimum formula and to determine the antioxidant activity of the gel preparation. Gel preparations were made with a 0.2% butterfly pea flower extract content on the basis of HPMC and carbopol. Each formula was prepared and tested for its physical properties including organoleptic, homogeneity, pH, viscosity, dispersibility and adhesion. The composition of HPMC and carbopol is determined by the Simplex Lattice Design method using Design Expert 12. The experimental results and SLD predictions were validated by using the one sample t-test with a confidence level of 95%. The optimum formula was tested for antioxidant activity with the FRAP (Ferric Reducing Antioxidant Power) method and was analyzed using a UV-Vis spectrophotometer at a wavelength of 704 nm using quercetin as a comparison. The optimum formula for butterfly pea flower ethanol extract gel consists of 4.5% HPMC and 0.5% carbopol. The results of the physical properties test obtained a homogeneous gel with a pH value of 5, viscosity of 600 dPa.S, spreadability of 6.06 cm2 , and adhesion of 2.14 seconds. Based on data analysis, the average value of the antioxidant activity of butterfly pea flower extract (Clitoria ternatea L) was 12,743±1,457 mgQE/g sample, meaning that each gram of sample contained 12,743 mgQE which was equivalent to the quercetin standard. This shows that the butterfly pea flower extract has antioxidant activity equivalent to quercetin.
Butterfly pea flower (Clitoria ternatea L) has been studied to contain phenolic and flavonoid chemicals which have antioxidant activity. Butterfly pea flower extract is formulated in a gel dosage form with a combination of HPMC and carbopol. in order to produce a gel with better physical properties than single use. This study aims to examine the effect of variations in the concentration of HPMC and carbopol on the physical properties of the gel, in order to produce the optimum formula and to determine the antioxidant activity of the gel preparation. Gel preparations were made with a 0.2% butterfly pea flower extract content on the basis of HPMC and carbopol. Each formula was prepared and tested for its physical properties including organoleptic, homogeneity, pH, viscosity, dispersibility and adhesion. The composition of HPMC and carbopol is determined by the Simplex Lattice Design method using Design Expert 12. The experimental results and SLD predictions were validated by using the one sample t-test with a confidence level of 95%. The optimum formula was tested for antioxidant activity with the FRAP (Ferric Reducing Antioxidant Power) method and was analyzed using a UV-Vis spectrophotometer at a wavelength of 704 nm using quercetin as a comparison. The optimum formula for butterfly pea flower ethanol extract gel consists of 4.5% HPMC and 0.5% carbopol. The results of the physical properties test obtained a homogeneous gel with a pH value of 5, viscosity of 600 dPa.S, spreadability of 6.06 cm2 , and adhesion of 2.14 seconds. Based on data analysis, the average value of the antioxidant activity of butterfly pea flower extract (Clitoria ternatea L) was 12,743±1,457 mgQE/g sample, meaning that each gram of sample contained 12,743 mgQE which was equivalent to the quercetin standard. This shows that the butterfly pea flower extract has antioxidant activity equivalent to quercetin.
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