OPTIMASI FORMULA PATCH TRANSDERMAL ANTIOKSIDAN
EKSTRAK DAUN BELIMBING WULUH (Averrhoa bilimbi L.)
DENGAN MATRIKS HIDROKSIPROPIL METILSELULOSA DAN
POLIVINILPIROLIDON
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Nurma, Astri Apriyani
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2020-12-23 06:31:28
Abstract :
Belimbing wuluh leaf extract (Averrhoa bilimbi L.) has very strong antioxidants. Wuluh starfruit extract needs to be made into preparations, one of which is a transdermal patch for easy use, and is not sticky and can be easily applied to the skin. This study aims to determine the optimal comparison of the use of HPMC and PVP matrices for transdermal patch preparations, and to determine the potential for antioxidant activity of transdermal patch preparations of starfruit leaf extract. Optimization of the formula for transdermal patch preparations of belimbing wuluh leaf extract with a concentration of 30ppm with a comparison of the combination of HPMC and PVP obtained from the Design Expert software version 12 using Simplex Lattice Design. The responses used included organoleptic, weight uniformity test, thickness, pH, crease resistance. Verification of the optimum formula with the One Sample T-test on SPSS. Antioxidant activity test on the optimum formula using ABTS. Operating time in the 6th minute and a maximum wavelength of 734 nm using a uv-vis spectrophotometer. The results of the analysis showed that the ratio of HPMC and PVP was 0.09 grams: 0.09 grams, resulting in a desirability value of 0.976. The weight test value is 0.78 ± 0.01, the pH test is 6.0 ± 0, the folding power test is 255.00 ± 0 and the thickness test is 0.23 ± 0, the test results of the weight test value between the optimal formulas and the prediction of simplex lattice design with One sample Ttest showed a significant difference, whereas in the pH test, thickness and folding power showed no significant difference, which means valid. The results of antioxidant testing on transdermal patch preparations had antioxidant activity values with an average IC50 of 46.43 ± 0.07 which was classified as very strong.
Belimbing wuluh leaf extract (Averrhoa bilimbi L.) has very strong antioxidants. Wuluh starfruit extract needs to be made into preparations, one of which is a transdermal patch for easy use, and is not sticky and can be easily applied to the skin. This study aims to determine the optimal comparison of the use of HPMC and PVP matrices for transdermal patch preparations, and to determine the potential for antioxidant activity of transdermal patch preparations of starfruit leaf extract. Optimization of the formula for transdermal patch preparations of belimbing wuluh leaf extract with a concentration of 30ppm with a comparison of the combination of HPMC and PVP obtained from the Design Expert software version 12 using Simplex Lattice Design. The responses used included organoleptic, weight uniformity test, thickness, pH, crease resistance. Verification of the optimum formula with the One Sample T-test on SPSS. Antioxidant activity test on the optimum formula using ABTS. Operating time in the 6th minute and a maximum wavelength of 734 nm using a uv-vis spectrophotometer. The results of the analysis showed that the ratio of HPMC and PVP was 0.09 grams: 0.09 grams, resulting in a desirability value of 0.976. The weight test value is 0.78 ± 0.01, the pH test is 6.0 ± 0, the folding power test is 255.00 ± 0 and the thickness test is 0.23 ± 0, the test results of the weight test value between the optimal formulas and the prediction of simplex lattice design with One sample Ttest showed a significant difference, whereas in the pH test, thickness and folding power showed no significant difference, which means valid. The results of antioxidant testing on transdermal patch preparations had antioxidant activity values with an average IC50 of 46.43 ± 0.07 which was classified as very strong.
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