UJI AKTIVITAS ANTIINFLAMASI SEDIAAN KRIM EKSTRAK
ETANOL DAUN PACAR AIR (Impatiens balsamina L)
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Satria, Pamungkas
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2020-12-23 06:36:20
Abstract :
The Indonesia people recognize and use medicinal plants as an effort to overcome health problems. One of the medicinal plants to cure inflammation is Impatiens balsamina leaves. This study aims to determine the anti-inflammatory activity of the ethanol extract of the Impatiens balsamina extract cream and to determine the concentration of the ethanol extract of the Impatiens balsamina leaves in the cream which has anti-inflammatory activity. Cream making was carried out at several concentrations of ethanol extract of Impatiens balsamina leaves, namely 2, 4, and 6%. The anti-inflammatory activity test was carried out on 5 treatment groups, each group of 5 rats by slashing on the back. Hydrocortisone cream 2.5% was used as positive control and cream-based negative control was used. The parameters measured were the speed at which the wound healed. The data from the anti-inflammatory activity test were statistically tested using one-way ANOVA and independent t test. The results of the anti-inflammatory activity test showed that the Impatiens balsamina leaf extract cream had anti-inflammatory activity, independent t test against formula 3 with positive control obtained a significance value (0.070> 0.05) meaning that there was no significant difference between formula 3 cream and positive control. In conclusion, the ethanol extract of Impatiens balsamina has anti-inflammatory activity and in formula 3 the 6% concentration of the extract has an anti-inflammatory activity comparable to that of the control, which can heal wounds within 5-6 days.
The Indonesia people recognize and use medicinal plants as an effort to overcome health problems. One of the medicinal plants to cure inflammation is Impatiens balsamina leaves. This study aims to determine the anti-inflammatory activity of the ethanol extract of the Impatiens balsamina extract cream and to determine the concentration of the ethanol extract of the Impatiens balsamina leaves in the cream which has anti-inflammatory activity. Cream making was carried out at several concentrations of ethanol extract of Impatiens balsamina leaves, namely 2, 4, and 6%. The anti-inflammatory activity test was carried out on 5 treatment groups, each group of 5 rats by slashing on the back. Hydrocortisone cream 2.5% was used as positive control and cream-based negative control was used. The parameters measured were the speed at which the wound healed. The data from the anti-inflammatory activity test were statistically tested using one-way ANOVA and independent t test. The results of the anti-inflammatory activity test showed that the Impatiens balsamina leaf extract cream had anti-inflammatory activity, independent t test against formula 3 with positive control obtained a significance value (0.070> 0.05) meaning that there was no significant difference between formula 3 cream and positive control. In conclusion, the ethanol extract of Impatiens balsamina has anti-inflammatory activity and in formula 3 the 6% concentration of the extract has an anti-inflammatory activity comparable to that of the control, which can heal wounds within 5-6 days.
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