UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN KERSEN
(Muntingia calabura L.) TERHADAP BAKTERI Escherichia coli ESBL
DAN Proteus mirabilis
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Wakhidah, Indriyani
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2020-12-23 06:36:23
Abstract :
Diabetic ulcers are chronic infections caused by bacterial, aerobic or anaerobic infections Escherichia coli ESBL and Proteus mirabilis are bacteria that are often found to infect diabetic ulcers, and have developed resistance to antibiotics. Kersen leaves (Muntingia calabura L.) are known to have antibacterial properties that can be used as an alternative treatment. The purpose of this study was to prove the inhibition of 96% ethanol extract of cherry leaves against Escherichia coli ESBL and Proteus mirabilis. This study used a descriptive experimental design with variations in concentration, namely 100%, 75%, 50%, 25%. In this study used Gentamycin 10 µg was used as a positive control and DMSO 10% as a negative control. The data of this study were analyzed using the One Way Anova statistical test to see the difference in the diameter of the inhibition zone from the negative control namely DMSO 10% and Gentamycin 10 µg positive control. The result of this research was that kersen leaf extract with 96% ethanol solvent was able to inhibit Escherichia coli ESBL bacteria at a concentration of 100% of 13,8 mm with a value of p=0,002 (p<0,05), which means that it is significantly different from the negative control DMSO 10%. The results of this research were that kersen leaf extract with 96% ethanol solvent was able to inhibit Proteus mirabilis bacteria at a concentration of 100% of 15,2 mm with a value of p=0,000 (p<0,05) which was significantly different from the negative control DMSO 10%. This value is not equivalent to the positive control Gentamycin 10 µg in Escherichia coli ESBL was 15,66 mm and in Proteus mirabilis was 23,77 mm.
Diabetic ulcers are chronic infections caused by bacterial, aerobic or anaerobic infections Escherichia coli ESBL and Proteus mirabilis are bacteria that are often found to infect diabetic ulcers, and have developed resistance to antibiotics. Kersen leaves (Muntingia calabura L.) are known to have antibacterial properties that can be used as an alternative treatment. The purpose of this study was to prove the inhibition of 96% ethanol extract of cherry leaves against Escherichia coli ESBL and Proteus mirabilis. This study used a descriptive experimental design with variations in concentration, namely 100%, 75%, 50%, 25%. In this study used Gentamycin 10 µg was used as a positive control and DMSO 10% as a negative control. The data of this study were analyzed using the One Way Anova statistical test to see the difference in the diameter of the inhibition zone from the negative control namely DMSO 10% and Gentamycin 10 µg positive control. The result of this research was that kersen leaf extract with 96% ethanol solvent was able to inhibit Escherichia coli ESBL bacteria at a concentration of 100% of 13,8 mm with a value of p=0,002 (p<0,05), which means that it is significantly different from the negative control DMSO 10%. The results of this research were that kersen leaf extract with 96% ethanol solvent was able to inhibit Proteus mirabilis bacteria at a concentration of 100% of 15,2 mm with a value of p=0,000 (p<0,05) which was significantly different from the negative control DMSO 10%. This value is not equivalent to the positive control Gentamycin 10 µg in Escherichia coli ESBL was 15,66 mm and in Proteus mirabilis was 23,77 mm.
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