FORMULASI GEL ANTIBAKTERI EKSTRAK BUAH PARE
(Momordica charantia l.) DENGAN GELLING AGENT CMC-NA
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Rista, Yuliana Wardani
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2020-12-23 02:24:21
Abstract :
Bitter melon (Momordica charantia L.) is a plant that contains chemical compounds flavonoids that function as antibacterial. The bitter melon fruit in this study was formulated into an antibacterial gel extract of ethanol extract of bitter melon with CMC Na gelling agent. Gel preparations provide a cooling effect on the skin when used. This study aims to determine the effect of adding CMC Na to the physical properties and stability of gel preparations. This type of research is included in experimental research, with the independent variable CMC Na concentrations of 3%, 4%, and 5%. The parameters seen were organoleptic, homogenity, pH, viscosity, adhesion, spreadability, acceptability, and effectiveness test on Staphylococcus aureus bacteria. The data obtained are compared with the requirements and other library parameters and analyzed using Oneway ANOVA statistics. From the research, it can be concluded that there is an influence of the difference in CMC Na base concentration on the physical properties of bitter melon extract gel (Momordica charantia L.). The results of the research and data analysis show that those who have the best physical properties include organoleptic, homogenity, pH, viscosity, spreadability, acceptability. The stable CMC Na concentration in storage is 5%. The effectiveness of the bitter melon extract gel with CMC Na 5% concentration on Staphylococcus aureus bacteria has an active inhibitory value with a diameter of 12.62 mm.
Bitter melon (Momordica charantia L.) is a plant that contains chemical compounds flavonoids that function as antibacterial. The bitter melon fruit in this study was formulated into an antibacterial gel extract of ethanol extract of bitter melon with CMC Na gelling agent. Gel preparations provide a cooling effect on the skin when used. This study aims to determine the effect of adding CMC Na to the physical properties and stability of gel preparations. This type of research is included in experimental research, with the independent variable CMC Na concentrations of 3%, 4%, and 5%. The parameters seen were organoleptic, homogenity, pH, viscosity, adhesion, spreadability, acceptability, and effectiveness test on Staphylococcus aureus bacteria. The data obtained are compared with the requirements and other library parameters and analyzed using Oneway ANOVA statistics. From the research, it can be concluded that there is an influence of the difference in CMC Na base concentration on the physical properties of bitter melon extract gel (Momordica charantia L.). The results of the research and data analysis show that those who have the best physical properties include organoleptic, homogenity, pH, viscosity, spreadability, acceptability. The stable CMC Na concentration in storage is 5%. The effectiveness of the bitter melon extract gel with CMC Na 5% concentration on Staphylococcus aureus bacteria has an active inhibitory value with a diameter of 12.62 mm.
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