UJI HEPATOPROTEKTOR JUS BROKOLI (Brassica oleracea L
Var Italica) TERHADAP KADAR SGOT TIKUS GALUR
WISTAR YANG DIINDUKSI PARASETAMOL
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Diana, Mei Karmelli
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2021-03-02 03:51:39
Abstract :
The liver is an organ as a place for metabolism and detoxification of toxins. Liver disease in Indonesia ranks third with paracetamol as one of the causes, because it is hepatotoxic if used in large and long-term doses, so that it is free radicals, characterized by high levels of SGOT in the body causing cell damage, but can be prevented by antioxidants, one of which found in broccoli. The flavonoid content is thought to be antioxidant. The purpose of this study was to determine the effect of broccoli juice on SGOT levels of wistar strain rats induced by paracetamol. This experimental study used 30 rats, with 6 treatments namely normal control (aquadest), positive control (silimarin), negative control (paracetamol), and dose I broccoli juice (12,6 g / kgBW), dose II (25,2 g / kgBW), and dose III (37,8 g / kgBW). The study was conducted 7 days, the 9th day was taken a blood sample through the eye vein to identify SGOT levels and macroscopic observation of the liver. Analysis of the data used is One Way Anova because the data is homogeneous, followed by the Post Hoc Test to compare the significance values between treatment groups. The results show that among the three doses, dose III is the optimal dose in reducing SGOT levels, because average SGOT levels of dose III with positive control the difference is not significant or the same, so that the ability of dose III reducing SGOT levels is the same as silimaryn.
The liver is an organ as a place for metabolism and detoxification of toxins. Liver disease in Indonesia ranks third with paracetamol as one of the causes, because it is hepatotoxic if used in large and long-term doses, so that it is free radicals, characterized by high levels of SGOT in the body causing cell damage, but can be prevented by antioxidants, one of which found in broccoli. The flavonoid content is thought to be antioxidant. The purpose of this study was to determine the effect of broccoli juice on SGOT levels of wistar strain rats induced by paracetamol. This experimental study used 30 rats, with 6 treatments namely normal control (aquadest), positive control (silimarin), negative control (paracetamol), and dose I broccoli juice (12,6 g / kgBW), dose II (25,2 g / kgBW), and dose III (37,8 g / kgBW). The study was conducted 7 days, the 9th day was taken a blood sample through the eye vein to identify SGOT levels and macroscopic observation of the liver. Analysis of the data used is One Way Anova because the data is homogeneous, followed by the Post Hoc Test to compare the significance values between treatment groups. The results show that among the three doses, dose III is the optimal dose in reducing SGOT levels, because average SGOT levels of dose III with positive control the difference is not significant or the same, so that the ability of dose III reducing SGOT levels is the same as silimaryn.
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