FORMULASI TABLET EKSTRAK DAUN SIRIH HIJAU
(Piper betle L.) DENGAN VARIASI AMILUM MANIHOT
SEBAGAI BAHAN PENGHANCUR
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Fitriyani, Ida Estiana Dewi
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2021-03-02 03:52:57
Abstract :
Green betel leaf (Piper betle L.) is one of the herbal plants which has antibacterial power because of the presence of various active substances contained therein such as essential oils, flavonoids, saponins, and polyphenols. The content of essential oils of green betel leaf contains 4.2%, most of which are chavica betel, isomer eugenol allypyrocatechine, chhineol, methyl eugenol and caryophyllen, kavikol, cavibekol, estragil, terpenin, saponin, and tannins. Flavonoids in addition to being bacteriostatic also function as antiinflammatory. Amilum manihot is added as a tablet crushing agent to facilitate the breakage or destruction of tablets because starch can attract water into the tablet, expand and cause the tablet to break into its parts. In this study aimed to determine the effect of the concentration of starch destroyer manihot on the physical properties of tablets and to find out at what concentration of starch manihot as a destroyer can produce good disintegration. The method used in this study is the wet granulation method because the active ingredient of the green betel leaf is flavonoids that cannot withstand temperatures above 50ºC based on these characteristics, so tablets can be made by wet granulation method with a temperature of 40-60 ° C. The wet granulation method can improve the flow properties and compactibility of the material so that it becomes easier when making tablets. Tablet formulations using amilum manihot crusher with a concentration of 5%, 10% and 15% are expected to produce tablets that meet the requirements of tablet weight uniformity test, tablet size uniformity test, tablet fragility test, tablet hardness test, and tablet disintegration time test during storage 28 day. Concentration of starch shredder manihot affect the good disintegration time of tablets at a concentration of 15% with an average weight uniformity test results of 0.51 ± 0.0362 grams, the average size uniformity test results of 0.499 ± 0.037, average fragility test results 0.00%, the average tablet hardness test results were 5.684 ± 1.0294 and the average results of the crushing time of tablets were 4: 20 ± 0: 30 minutes.
Green betel leaf (Piper betle L.) is one of the herbal plants which has antibacterial power because of the presence of various active substances contained therein such as essential oils, flavonoids, saponins, and polyphenols. The content of essential oils of green betel leaf contains 4.2%, most of which are chavica betel, isomer eugenol allypyrocatechine, chhineol, methyl eugenol and caryophyllen, kavikol, cavibekol, estragil, terpenin, saponin, and tannins. Flavonoids in addition to being bacteriostatic also function as antiinflammatory. Amilum manihot is added as a tablet crushing agent to facilitate the breakage or destruction of tablets because starch can attract water into the tablet, expand and cause the tablet to break into its parts. In this study aimed to determine the effect of the concentration of starch destroyer manihot on the physical properties of tablets and to find out at what concentration of starch manihot as a destroyer can produce good disintegration. The method used in this study is the wet granulation method because the active ingredient of the green betel leaf is flavonoids that cannot withstand temperatures above 50ºC based on these characteristics, so tablets can be made by wet granulation method with a temperature of 40-60 ° C. The wet granulation method can improve the flow properties and compactibility of the material so that it becomes easier when making tablets. Tablet formulations using amilum manihot crusher with a concentration of 5%, 10% and 15% are expected to produce tablets that meet the requirements of tablet weight uniformity test, tablet size uniformity test, tablet fragility test, tablet hardness test, and tablet disintegration time test during storage 28 day. Concentration of starch shredder manihot affect the good disintegration time of tablets at a concentration of 15% with an average weight uniformity test results of 0.51 ± 0.0362 grams, the average size uniformity test results of 0.499 ± 0.037, average fragility test results 0.00%, the average tablet hardness test results were 5.684 ± 1.0294 and the average results of the crushing time of tablets were 4: 20 ± 0: 30 minutes.
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