OPTIMASI FORMULA GEL NANOPARTIKEL EKSTRAK
ETANOL DAUN SIRIH (Piper betle L.) DENGAN VARIASI
KARBOPOL DAN HPMC MENGGUNAKAN METODE
SIMPLEX LATTICE DESIGN
Total View This Week0
Total View This Week0
Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Natasha, Intania Pertiwi
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2021-03-02 03:53:56
Abstract :
Green betel (Piper betle L.) contains active compound flavonoid that had antibacterial activity against Staphylococcus aureus which is one of the bacteria that cause acne. Flavonoid had low lipid solubility and poorly absorbed by the skin. Nanoparticles used to increase the penetration of active substances through the stratum corneum. Gel can easily penetrate to the skin that gives healing effect. The aim of this research to made a formulation gel nanoparticles of ethanol extract of betel leaf with an optimal variation of carbopol and HPMC with the Simplex Lattice Design (SLD) method. Betel leaf extraction used maceration method with 70% ethanol solvent. Nanoparticles were made by ionic gelation method with alginate 0,1% and CaCl2 0,02% polymers. Optimal formula is obtained by the SLD method using Design Expert 10 software with parameters pH, viscosity, spreadability, adhesion, antibacterial activity. Verification optimal formula using the One sample t-test, the stability with cycling test method, and acceptability test. The result of optimal formula showed carbopol concentration of 80.9% and HPMC 19.1%. Based the verification, the predictions with the test results were insignificantly different indicated by p values > 0.05 showed method is valid to describe the response as expected. The optimal formula gel has good physical stability and can be accepted by people.
Green betel (Piper betle L.) contains active compound flavonoid that had antibacterial activity against Staphylococcus aureus which is one of the bacteria that cause acne. Flavonoid had low lipid solubility and poorly absorbed by the skin. Nanoparticles used to increase the penetration of active substances through the stratum corneum. Gel can easily penetrate to the skin that gives healing effect. The aim of this research to made a formulation gel nanoparticles of ethanol extract of betel leaf with an optimal variation of carbopol and HPMC with the Simplex Lattice Design (SLD) method. Betel leaf extraction used maceration method with 70% ethanol solvent. Nanoparticles were made by ionic gelation method with alginate 0,1% and CaCl2 0,02% polymers. Optimal formula is obtained by the SLD method using Design Expert 10 software with parameters pH, viscosity, spreadability, adhesion, antibacterial activity. Verification optimal formula using the One sample t-test, the stability with cycling test method, and acceptability test. The result of optimal formula showed carbopol concentration of 80.9% and HPMC 19.1%. Based the verification, the predictions with the test results were insignificantly different indicated by p values > 0.05 showed method is valid to describe the response as expected. The optimal formula gel has good physical stability and can be accepted by people.
Download
book
BibTex
Latex, Jabref
cloud_download
Original Resource
url resource Institution
