UJI AKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK
ETANOL BUAH PARE (Momordica charantia L.) DAN
EKSTRAK ETANOL BUAH TOMAT (Solanum lycopersicum)
SECARA IN VITRO
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Ayu, Septina Dwi Lestari
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2020-12-23 02:24:35
Abstract :
Bitter melon fruit (Momordica charantia L.) and tomatoes (Solanum lycopersicum) are known to contain compounds that are beneficial for health, one of which is used as an antidiabetic. This study aims to determine the antidiabetic activity of the combination of ethanol extract of bitter melon fruit (Momordica charantia L.) and ethanol extract of tomatoes (Solanum lycopersicum) which are the most effective as antidiabetic. The method used in this study is a visible spectrophotometric method using nelson reagent which is measured at a wavelength of 748.1 nm and operating time (OT) in the 25th minute. The qualitative test results showed that 96% ethanol extract of bitter melon and tomato fruit contained alkaloid, flavonoid and terpenoid compounds. The results of the testing of antidiabetic activity were a combination of 96% ethanol extract of bitter melon fruit and tomatoes with a ratio of 1:0, 1:2, 2:1, and 0:1 respectively which resulted in a value of EC50 4.9273; 4,4954; 4,6034; and 4,7688 ppm. Based on the data obtained, it can be concluded that the combination of 96% ethanol extract of bitter melon fruit and 96% ethanol extract of tomatoes with a ratio of 1: 2 has the most effective antidiabetic activity from its single form with an EC50 value of 4,4954 ppm.
Bitter melon fruit (Momordica charantia L.) and tomatoes (Solanum lycopersicum) are known to contain compounds that are beneficial for health, one of which is used as an antidiabetic. This study aims to determine the antidiabetic activity of the combination of ethanol extract of bitter melon fruit (Momordica charantia L.) and ethanol extract of tomatoes (Solanum lycopersicum) which are the most effective as antidiabetic. The method used in this study is a visible spectrophotometric method using nelson reagent which is measured at a wavelength of 748.1 nm and operating time (OT) in the 25th minute. The qualitative test results showed that 96% ethanol extract of bitter melon and tomato fruit contained alkaloid, flavonoid and terpenoid compounds. The results of the testing of antidiabetic activity were a combination of 96% ethanol extract of bitter melon fruit and tomatoes with a ratio of 1:0, 1:2, 2:1, and 0:1 respectively which resulted in a value of EC50 4.9273; 4,4954; 4,6034; and 4,7688 ppm. Based on the data obtained, it can be concluded that the combination of 96% ethanol extract of bitter melon fruit and 96% ethanol extract of tomatoes with a ratio of 1: 2 has the most effective antidiabetic activity from its single form with an EC50 value of 4,4954 ppm.
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