UJI AKTIVITAS ANTIKOLESTEROL SARI DAUN MELINJO
(Gnetum gnemon L.) SECARA IN VITRO
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Hanni, Retno Astuti
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2021-03-02 03:57:00
Abstract :
Cholesterol is a component of fat, if there is too much fat in the body it will cause fatty liver. This study aims to determine the anti-cholesterol activity of melinjo leaf extract with different concentrations. This type of research is experimental. Melinjo leaf extract was tested for phytochemical screening. Cholesterol concentration analysis using the Lieberman Burchard method measured by UV-Vis spectrophotometry with operating time at the 15th minute and at a maximum wavelength of 668 nm. The concentration of melinjo leaf extract solution used were 5%, 10%, 15%, 20%, 25%. Phytochemical screening test results of melinjo leaf extract contain saponins, tannins, steroids and terpenoids, vitamin C, and flavonoids. The average result of anticholesterol reduction in melinjo leaf extract successively at concentrations of 5%, 10%, 15%, 20%, 25% was 36.02% (KV = 0.4719%), 38.94% (KV = 0, 5785%), 41.50% (KV = 0.4096%), 45.11% (KV = 0.2174%), 49.26% (KV = 1.4139%). The greatest concentration to reduce cholesterol is 25% which can reduce cholesterol by 49.26%. The linearity value between the percent decrease in cholesterol levels with the concentration of melinjo leaf extract was 0.9906. This shows a very strong relationship where the greater the concentration of melinjo leaf extract, the greater the anti-cholesterol activity.
Cholesterol is a component of fat, if there is too much fat in the body it will cause fatty liver. This study aims to determine the anti-cholesterol activity of melinjo leaf extract with different concentrations. This type of research is experimental. Melinjo leaf extract was tested for phytochemical screening. Cholesterol concentration analysis using the Lieberman Burchard method measured by UV-Vis spectrophotometry with operating time at the 15th minute and at a maximum wavelength of 668 nm. The concentration of melinjo leaf extract solution used were 5%, 10%, 15%, 20%, 25%. Phytochemical screening test results of melinjo leaf extract contain saponins, tannins, steroids and terpenoids, vitamin C, and flavonoids. The average result of anticholesterol reduction in melinjo leaf extract successively at concentrations of 5%, 10%, 15%, 20%, 25% was 36.02% (KV = 0.4719%), 38.94% (KV = 0, 5785%), 41.50% (KV = 0.4096%), 45.11% (KV = 0.2174%), 49.26% (KV = 1.4139%). The greatest concentration to reduce cholesterol is 25% which can reduce cholesterol by 49.26%. The linearity value between the percent decrease in cholesterol levels with the concentration of melinjo leaf extract was 0.9906. This shows a very strong relationship where the greater the concentration of melinjo leaf extract, the greater the anti-cholesterol activity.
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