OPTIMASI CAMPURAN GELATIN DAN PVP SEBAGAI
BAHAN PENGIKAT TABLET EKSTRAK DAUN JAMBU BIJI
(Psidium guajava L.) SECARA GRANULASI BASAH
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Vernanda, Rezha Aryuda
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2021-03-02 03:59:08
Abstract :
Guava leaf plant is a type of medicinal plant used by the community. Flavonoids are one of the nutritious compounds contained in guava leaves (Psidium guajava L). Tablets have the advantage of being easy to take and the exact dose. The purpose of this study was to obtain an optimum formula of a mixture of gelatin and PVP as a binding agent that can produce guava leaf extract tablets with good physical quality and stability. The extraction method used is maceration with 70% ethanol solvent obtained 16.36% yield. The method of making tablets used is wet granulation by drying granules at a temperature of 50 ° C. Determination of the optimal formula with the Simplex Lattice Design method with Software Design Expert Version 10. Verification of the optimal formula with SPSS version 21, the method used One Sample T-test with parameters of weight uniformity test, size uniformity test, hardness test, friability test and disintegration time test . The stability test is carried out on days 0, 7, 14 and 21 which are presented in the form of line charts. Optimal formula obtained by comparison of the concentration of gelatin and PVP 4.74%: 5.26% with a weight of 17.739 mg and 19.661 mg at 374 mg of total weight of the tablet. Verification results were not significantly different, indicated by p value> 0.05 and had good stability.
Guava leaf plant is a type of medicinal plant used by the community. Flavonoids are one of the nutritious compounds contained in guava leaves (Psidium guajava L). Tablets have the advantage of being easy to take and the exact dose. The purpose of this study was to obtain an optimum formula of a mixture of gelatin and PVP as a binding agent that can produce guava leaf extract tablets with good physical quality and stability. The extraction method used is maceration with 70% ethanol solvent obtained 16.36% yield. The method of making tablets used is wet granulation by drying granules at a temperature of 50 ° C. Determination of the optimal formula with the Simplex Lattice Design method with Software Design Expert Version 10. Verification of the optimal formula with SPSS version 21, the method used One Sample T-test with parameters of weight uniformity test, size uniformity test, hardness test, friability test and disintegration time test . The stability test is carried out on days 0, 7, 14 and 21 which are presented in the form of line charts. Optimal formula obtained by comparison of the concentration of gelatin and PVP 4.74%: 5.26% with a weight of 17.739 mg and 19.661 mg at 374 mg of total weight of the tablet. Verification results were not significantly different, indicated by p value> 0.05 and had good stability.
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