DETAIL DOCUMENT
UJI AKTIVITAS HEPATOPROTEKTOR KOMBINASI EKSTRAK DAUN JAMBU BIJI (Psidium guajava L) DAN EKSTRAK KAYU MANIS (Cinnamomum burmanii) TERHADAP KADAR MALONDIALDEHID (MDA) PADA TIKUS YANG DIINDUKSI PARASETAMOL
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Woro, Larasati
Subject
RN Pharmacy and Pharmaceutical Mathematics 
Datestamp
2021-03-02 03:59:12 
Abstract :
Liver disease is a problem in various countries. Excessive use of paracetamol can increase the production of free radicals by various mechanisms so that it triggers oxidative stress. Oxidative stress can cause liver damage which is characterized by increased levels of malondialdehyde (MDA). Oxidative stress can be overcome by using antioxidants from outside the body found in various plants around. Guava leaves have antioxidant activity with IC50 values of 37.14 ppm. Cinnamon bark has antioxidant activity with an IC50 value of 8.4431 ppm. This study aims to determine the hepatoprotector activity of a combination of guava leaf extract and cinnamon extract in reducing MDA levels in paracetamol induced in rats. The method used in this study is an experimental method. The study was conducted for 9 days using 30 male rats divided into 6 groups. Group I (normal) were given aquadest, group II (negative control) were given 0.5% CMC Na, group III (positive control) were given 100 mg / kg BB silymarin, group IVVI were each given a combination of guava leaf extract and cinnamomum bark extract with a dose of 50 mg/kg BB: 240 mg /kg BB, 100 mg/kg BB: 160 mg/kg BB, 150 mg /kg BB: 80 mg /kgBB for 7 days. All groups were induced paracetamol 2,5g /kgBB on the 7th day orally except the normal group 30 minutes after the test sample was given. Then performed surgery on the 9th day and analyzed the determination of oxidative stress parameters by measuring MDA levels by the TBARS method. The results showed that the combined dose of guava leaf extract and cinnamon 50 mg /kg BB: 240 mg /kg BB, 100 mg /kg BB: 160 mg /kg BB, 150 mg /kg BB: 80 mg /kgBB. The combination of guava leaf and cinnamon leaf extract was able to reduce MDA levels in paracetamol-induced mice compared with the negative group significantly by value (P <0.05). The conclusion of this research is that the combination of guava leaf extract and cinnamon extract is able to function as a hepatoprotector in reducing MDA levels in rats induced by paracetamol with an optimal dose that can reduce MDA levels is 150 mg / kgBB: 80 mg / kgBBwith a p value of 0,145>0,000 compared to the positive group. 
Institution Info

Sekolah Tinggi Ilmu Kesehatan Nasional