Abstract :
Liver disease is a problem in various countries. Excessive use of
paracetamol can increase the production of free radicals by various mechanisms
so that it triggers oxidative stress. Oxidative stress can cause liver damage which
is characterized by increased levels of malondialdehyde (MDA). Oxidative stress
can be overcome by using antioxidants from outside the body found in various
plants around. Guava leaves have antioxidant activity with IC50 values of 37.14
ppm. Cinnamon bark has antioxidant activity with an IC50 value of 8.4431 ppm.
This study aims to determine the hepatoprotector activity of a combination of
guava leaf extract and cinnamon extract in reducing MDA levels in paracetamol
induced in rats. The method used in this study is an experimental method. The
study was conducted for 9 days using 30 male rats divided into 6 groups. Group I
(normal) were given aquadest, group II (negative control) were given 0.5% CMC
Na, group III (positive control) were given 100 mg / kg BB silymarin, group IVVI were each given a combination of guava leaf extract and cinnamomum bark
extract with a dose of 50 mg/kg BB: 240 mg /kg BB, 100 mg/kg BB: 160 mg/kg
BB, 150 mg /kg BB: 80 mg /kgBB for 7 days. All groups were induced
paracetamol 2,5g /kgBB on the 7th day orally except the normal group 30 minutes
after the test sample was given. Then performed surgery on the 9th day and
analyzed the determination of oxidative stress parameters by measuring MDA
levels by the TBARS method. The results showed that the combined dose of
guava leaf extract and cinnamon 50 mg /kg BB: 240 mg /kg BB, 100 mg /kg BB:
160 mg /kg BB, 150 mg /kg BB: 80 mg /kgBB. The combination of guava leaf
and cinnamon leaf extract was able to reduce MDA levels in paracetamol-induced
mice compared with the negative group significantly by value (P <0.05). The
conclusion of this research is that the combination of guava leaf extract and
cinnamon extract is able to function as a hepatoprotector in reducing MDA levels
in rats induced by paracetamol with an optimal dose that can reduce MDA levels
is 150 mg / kgBB: 80 mg / kgBBwith a p value of 0,145>0,000 compared to the
positive group.