UJI AKTIVITAS ANTIDIABETES EKSTRAK KALE
(Brassica oleracea var. sabellica) SECARA IN VITRO
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Afdrian, Kusumawardianingrum
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2021-11-16 08:10:54
Abstract :
Diabetes mellitus is a comorbid of the Covid-19 virus which is currently endemic in Indonesia. Prevention of diabetes mellitus has been mostly done by consuming vegetables that have antidiabetic activity. The study was conducted to see the activity of kale (Brassica oleracea var. sabellica) extract in reducing glucose levels. Kale was macerated extracted using 96% ethanol solvent. The kale extract obtained was analyzed for secondary metabolites. Determination of the decrease in glucose levels was carried out by the Nelson Somogyi method and the UV-Vis spectrophotometer instrument. Antidiabetic activity test was performed at the 25th minute of operation and a maximum ? of 745 nm. The results showed that kale extract was positive for flavonoids, tannins, triterpenoids and phenols. The percentage of decrease in glucose levels in the concentration of 4 ppm was 2,2251% ± 0,46, 6 ppm of 16,4664% ± 0,27, 8 ppm of 30,6186% ± 0,46, 10 ppm of 41,878 ± 0,27, 12 ppm of 55,4962 ± 0,20. The concentration of kale extract in reducing glucose up to 50% (EC50) was 11,1319 ppm.
Diabetes mellitus is a comorbid of the Covid-19 virus which is currently endemic in Indonesia. Prevention of diabetes mellitus has been mostly done by consuming vegetables that have antidiabetic activity. The study was conducted to see the activity of kale (Brassica oleracea var. sabellica) extract in reducing glucose levels. Kale was macerated extracted using 96% ethanol solvent. The kale extract obtained was analyzed for secondary metabolites. Determination of the decrease in glucose levels was carried out by the Nelson Somogyi method and the UV-Vis spectrophotometer instrument. Antidiabetic activity test was performed at the 25th minute of operation and a maximum ? of 745 nm. The results showed that kale extract was positive for flavonoids, tannins, triterpenoids and phenols. The percentage of decrease in glucose levels in the concentration of 4 ppm was 2,2251% ± 0,46, 6 ppm of 16,4664% ± 0,27, 8 ppm of 30,6186% ± 0,46, 10 ppm of 41,878 ± 0,27, 12 ppm of 55,4962 ± 0,20. The concentration of kale extract in reducing glucose up to 50% (EC50) was 11,1319 ppm.
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