UJI EFEK ANTIPIRETIK EKSTRAK ETANOL RIMPANG
TEMU IRENG (Curcuma Aeruginosa Roxb) PADA TIKUS
PUTIH JANTAN DENGAN INDUKSI RAGI
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Erlyna, Vita
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2022-04-14 06:41:25
Abstract :
Temu Ireng rhizome or Curcuma Aeruginosa Roxb is a plant that contains bioactive compounds, namely flavonoids, tannins, and phenolics that have many benefits, one of which is as an antipyretic. This study aims to determine the antipyretic effect on rats induced by yeast yeast at a dose of 25mg/200gBW; 50mg/200gBB; 100mg/200gBB. This study used 25 male white rats as experimental animals which were divided into 5 groups, namely negative control (CMC Na 1%), positive control (Paracetamol 45mg/kgBW), and 3 treatment groups with ethanol extract of temu ireng rhizome at a dose of 25mg/200gBW; 50mg/200gBB; 100mg/200gBB. The temperature of the mice was measured every 30 minutes for 150 minutes after oral administration which will be used as data for calculating AUC and the average AUC then analyzed by normality test and One Way ANOVA test. Based on the results of the study aimed to determine the antipyretic effect on rats induced by yeast yeast at a dose of 25mg/200gBW; 50mg/200gBB; 100mg/200gBB. The difference in the dose of the temu ireng rhizome extract did not cause any difference in effectiveness as an antipyretic in male white rats.
Temu Ireng rhizome or Curcuma Aeruginosa Roxb is a plant that contains bioactive compounds, namely flavonoids, tannins, and phenolics that have many benefits, one of which is as an antipyretic. This study aims to determine the antipyretic effect on rats induced by yeast yeast at a dose of 25mg/200gBW; 50mg/200gBB; 100mg/200gBB. This study used 25 male white rats as experimental animals which were divided into 5 groups, namely negative control (CMC Na 1%), positive control (Paracetamol 45mg/kgBW), and 3 treatment groups with ethanol extract of temu ireng rhizome at a dose of 25mg/200gBW; 50mg/200gBB; 100mg/200gBB. The temperature of the mice was measured every 30 minutes for 150 minutes after oral administration which will be used as data for calculating AUC and the average AUC then analyzed by normality test and One Way ANOVA test. Based on the results of the study aimed to determine the antipyretic effect on rats induced by yeast yeast at a dose of 25mg/200gBW; 50mg/200gBB; 100mg/200gBB. The difference in the dose of the temu ireng rhizome extract did not cause any difference in effectiveness as an antipyretic in male white rats.
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