Abstract :
Urinary Tract Infections (UTIs) are the most common infections acquired in
hospitals that result in significant morbidity. The pattern of bacterial resistance that
causes UTI will play an important role in the success of UTI treatment. The variety of
bacteria, including Escherichia coli and Pseudomonas aeruginosa, and the lack of clinical
trials of antibiotics carried out make it difficult for doctors to choose drugs. The purpose
of this study was to determine the trend of resistance of Escherichia coli and
Pseudomonas aeruginosa bacteria to amikacin and meropenem antibiotics at the Klaten
Islamic Hospital for the 2019-2020 period.
The method of this research is descriptive retrospective sampling technique in
this study is purpose sampling. period 2019-2020 The subject of this study on urinary
tract infections with urine objects examined for sensitivity culture, a regression test was
carried out to determine the level of the variable.
The results of the study with a total of 144 cases, 75 cases caused by Escherichia coli and
69 cases caused by Pseudomonas aeruginosa and the results were processed by
regression tests to determine the level of correlation between antibiotic use and bacterial
resistance, Escherichia coli to amikacin and meropenem, the value of y = - ( negative)
0.0874 and R2 0.2376, Pseudomonas aeruginosa bacteria against amikacin values y = -
(negative) 0.0378 and R2 0.0860 and Pseudomonas aeruginosa bacteria against
meropenem values y = - (negative) 0.0874 and R2 0 ,2376 which means that there is a
downward trend of bacterial resistance with weak data.