OPTIMASI FORMULA KRIM EKSTRAK ETANOL DAUN KELOR (Moringa
Oleifera Lamk.) MENGGUNAKAN EMULGATOR TWEEN 80 DAN SPAN 80
SEBAGAI ANTIOKSIDAN DENGAN METODE FRAP
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Annisa, Nur Nariswari
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2022-04-14 07:40:21
Abstract :
Moringa leaf (Moringa oleifera Lamk.) is one of the plants that has antioxidant activity. Moringa leaf ethanol extract has been studied to have good antioxidant ability. The purpose of this study was to obtain the optimum cream formula with good physical properties and antioxidant activity test. The method used in this optimization is Simplex Lattice Design. The advantages of cream preparations are easy to spread evenly, easy to use and easy to clean or wash. The results showed that the optimum cream formula consisted of 1.272% tween 80 and 9.728% with 3% Moringa leaf ethanol extract. The optimum formula of the cream was made with the composition of tween 80 and span 80. The parameters of the physical properties measured were viscosity 2500 (cps), pH 6, spreadability 5.10 (cm), positioning power 1.60 (seconds). Verification using t-test then the optimum formula was tested for antioxidants using the FRAP method. Moringa leaf ethanol extract cream produced from the optimum formula verified using one sample t-test obtained a significant value > 0.05, which means there is no significant difference. The optimum formula of the ethanolic extract of Moringa leaves has an antioxidant activity value of 3.44 ± 0.36 mgQE/g, meaning that each gram of sample contains 3.44 mgQE which is equivalent to quercetin standard. This shows that Moringa leaf extract has antioxidant activity equivalent to quercetin.
Moringa leaf (Moringa oleifera Lamk.) is one of the plants that has antioxidant activity. Moringa leaf ethanol extract has been studied to have good antioxidant ability. The purpose of this study was to obtain the optimum cream formula with good physical properties and antioxidant activity test. The method used in this optimization is Simplex Lattice Design. The advantages of cream preparations are easy to spread evenly, easy to use and easy to clean or wash. The results showed that the optimum cream formula consisted of 1.272% tween 80 and 9.728% with 3% Moringa leaf ethanol extract. The optimum formula of the cream was made with the composition of tween 80 and span 80. The parameters of the physical properties measured were viscosity 2500 (cps), pH 6, spreadability 5.10 (cm), positioning power 1.60 (seconds). Verification using t-test then the optimum formula was tested for antioxidants using the FRAP method. Moringa leaf ethanol extract cream produced from the optimum formula verified using one sample t-test obtained a significant value > 0.05, which means there is no significant difference. The optimum formula of the ethanolic extract of Moringa leaves has an antioxidant activity value of 3.44 ± 0.36 mgQE/g, meaning that each gram of sample contains 3.44 mgQE which is equivalent to quercetin standard. This shows that Moringa leaf extract has antioxidant activity equivalent to quercetin.
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