OPTIMASI POLYVINYL ALKOHOL DAN CARBOMER PADA
FORMULASI SEDIAAN MASKER GEL PEEL – OFF MINYAK ATSIRI
DAUN JERUK PURUT (Citrus hystrix D.C) SEBAGAI ANTIOKSIDAN
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Diah, Kartika Dewi
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2022-04-14 07:40:42
Abstract :
Kaffir lime leaf essential oil is known to have many benefits, including as an antioxidant. This study aims to determine the peel-off gel mask of kaffir lime leaf essential oil (Citrus hystrix D.C) with the most optimum composition of PVA and carbomer having antioxidant activity. Determination of the optimum formula for the peel-off gel mask was carried out using Design Expert software version 11 of the Simple Lattice Design method, which obtained eight run formulas which were then tested for their physical characteristics in the form of pH, adhesion, spreadability, viscosity, and drying time. The results showed that the optimum composition of the peel-off gel mask formula was PVA 4% and carbomer 2% with a desirability value of 0.913. The resulting optimum formula was tested again for its physical characteristics and compared with the results obtained using the Simple Lattice Design method. The significance test for the prediction of the optimum formula with the results showed a significance with a pH value of 0.698, adhesion 0.841, spreadability 0.211, viscosity 0.352, and drying time 0.984, which means there is no significant difference between the predictions of Simple Lattice Design and the results of the study indicated by a significance value. each response is more than 0.05. The optimal formula for peel-off gel mask of kaffir lime leaf essential oil has antioxidant activity in the medium category with an IC50 value of 116.755 ppm.
Kaffir lime leaf essential oil is known to have many benefits, including as an antioxidant. This study aims to determine the peel-off gel mask of kaffir lime leaf essential oil (Citrus hystrix D.C) with the most optimum composition of PVA and carbomer having antioxidant activity. Determination of the optimum formula for the peel-off gel mask was carried out using Design Expert software version 11 of the Simple Lattice Design method, which obtained eight run formulas which were then tested for their physical characteristics in the form of pH, adhesion, spreadability, viscosity, and drying time. The results showed that the optimum composition of the peel-off gel mask formula was PVA 4% and carbomer 2% with a desirability value of 0.913. The resulting optimum formula was tested again for its physical characteristics and compared with the results obtained using the Simple Lattice Design method. The significance test for the prediction of the optimum formula with the results showed a significance with a pH value of 0.698, adhesion 0.841, spreadability 0.211, viscosity 0.352, and drying time 0.984, which means there is no significant difference between the predictions of Simple Lattice Design and the results of the study indicated by a significance value. each response is more than 0.05. The optimal formula for peel-off gel mask of kaffir lime leaf essential oil has antioxidant activity in the medium category with an IC50 value of 116.755 ppm.
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