OPTIMASI TWEEN 80 DAN SPAN 80 DALAM KRIM FRAKSI ETIL
ASETAT EKSTRAK ETANOL BUNGA ROSELLA (Hibiscus sabdariffa L)
DAN POTENSINYA SEBAGAI TABIR SURYA
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Fitriana, Fitriana
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2022-04-14 07:40:57
Abstract :
Excessive sun exposure causes sunburn, so protection is needed such as the use of sunscreen. Flavonoids and anthocyanins in rosella flower petals can reduce the intensity of exposure to the skin. This study aims to determine the effect of the comparison of the composition of tween 80 and span 80, as well as determining the optimum formula for physical characteristics using themethod Simplex Lattice Design and knowing the potential of the ethyl acetate fraction cream of rosella flower ethanol extract as a sunscreen. Rosella flowers were extracted by maceration method using 70% ethanol solvent for 5 days and remaceration for 2 days, followed by fractionation using a liquid-liquid extraction method using a separating funnel, then optimization of tween 80 and span 80 using themethod Simplex Lattice Design, then testing the potential of the screen. solar cream ethyl acetate fraction of rosella flower ethanol extract using UV-Vis spectrophotometer at a wavelength of 290-320 nm. Based on theequation, it is Simplex Lattice Design known the effect of each component and the interaction of the two components. Based onoptimization Design Expert 9.0.4, the combination of tween 80:span 80 = 8.423%:2.577 %. The optimum formula test results obtained pH 6,0 ± 0,577, viscosity 275 275 ± 5 dPa.s, adhesion 1.723 ± 0,005 second, dispersion of 6.466 ± 0,057 cm, and SPF value of 8.411,411± 0,08 which were included in the category of maximum protection.
Excessive sun exposure causes sunburn, so protection is needed such as the use of sunscreen. Flavonoids and anthocyanins in rosella flower petals can reduce the intensity of exposure to the skin. This study aims to determine the effect of the comparison of the composition of tween 80 and span 80, as well as determining the optimum formula for physical characteristics using themethod Simplex Lattice Design and knowing the potential of the ethyl acetate fraction cream of rosella flower ethanol extract as a sunscreen. Rosella flowers were extracted by maceration method using 70% ethanol solvent for 5 days and remaceration for 2 days, followed by fractionation using a liquid-liquid extraction method using a separating funnel, then optimization of tween 80 and span 80 using themethod Simplex Lattice Design, then testing the potential of the screen. solar cream ethyl acetate fraction of rosella flower ethanol extract using UV-Vis spectrophotometer at a wavelength of 290-320 nm. Based on theequation, it is Simplex Lattice Design known the effect of each component and the interaction of the two components. Based onoptimization Design Expert 9.0.4, the combination of tween 80:span 80 = 8.423%:2.577 %. The optimum formula test results obtained pH 6,0 ± 0,577, viscosity 275 275 ± 5 dPa.s, adhesion 1.723 ± 0,005 second, dispersion of 6.466 ± 0,057 cm, and SPF value of 8.411,411± 0,08 which were included in the category of maximum protection.
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