UJI AKTIVITAS ANTIBAKTERI SEDIAAN GEL ANTISEPTIK TANGAN
EKSTRAK ETANOL DAUN CENGKEH (Syzigium aromaticum L.)
TERHADAP BAKTERI Staphylococcus aureus.
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Nirmala, Celina Daylawati
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2022-04-14 07:41:50
Abstract :
Clove leaf (Syzigium aromaticum L.) is one of the plants that has potential as an antibacterial, where clove leaves contain several compounds, namely: flavonoids, tannins, alkaloids, saponins and phenols, which have antibacterial effectiveness. Gel can reduce the risk of dry skin due to washing your hands too often. This study aims to formulate hand antiseptic gel preparations from clove leaf ethanol extract (Syzigium aromaticum L.), and to test the antibacterial activity of the preparation againstbacteria Staphylococcus aureus, using CMC-Na base formulated in clove leaf ethanol extract antiseptic gel preparations. The extraction method used in this study is using the maceration method with 96% ethanol as solvent. Preparation of hand antiseptic gel preparation of clove leaf extract was carried out with three concentrations of clove leaf ethanol extract, namely: 5%, 10% and 15% concentration. Tests for quality control of gel preparations were: homogeneity, pH, spreadability, viscosity, and adhesion. The results of the physical properties test at concentrations of 5%, 10, and 15% had good physical qualities, respectively, with a pH value of 5; spreadability 6.55cm ±0.1; 5.50cm ±0.05; 5.12 cm ± 0.09; viscosity 300 dPa.s; 330 dPa.s.; 340 dPa.s, and adhesion 1.78sec±0.01; 1.79sec±0.01; 1.78sec ±0.03. The antibacterial activity test found that the hand antiseptic gel preparation of clove leaf ethanol extract had the ability to inhibitbacteria Staphylococcus aureus in the medium category with an inhibition zone of 8.88; 9.37 and 9.98 mm, with p-value <0.05, which means there is a significant difference in the concentration value..
Clove leaf (Syzigium aromaticum L.) is one of the plants that has potential as an antibacterial, where clove leaves contain several compounds, namely: flavonoids, tannins, alkaloids, saponins and phenols, which have antibacterial effectiveness. Gel can reduce the risk of dry skin due to washing your hands too often. This study aims to formulate hand antiseptic gel preparations from clove leaf ethanol extract (Syzigium aromaticum L.), and to test the antibacterial activity of the preparation againstbacteria Staphylococcus aureus, using CMC-Na base formulated in clove leaf ethanol extract antiseptic gel preparations. The extraction method used in this study is using the maceration method with 96% ethanol as solvent. Preparation of hand antiseptic gel preparation of clove leaf extract was carried out with three concentrations of clove leaf ethanol extract, namely: 5%, 10% and 15% concentration. Tests for quality control of gel preparations were: homogeneity, pH, spreadability, viscosity, and adhesion. The results of the physical properties test at concentrations of 5%, 10, and 15% had good physical qualities, respectively, with a pH value of 5; spreadability 6.55cm ±0.1; 5.50cm ±0.05; 5.12 cm ± 0.09; viscosity 300 dPa.s; 330 dPa.s.; 340 dPa.s, and adhesion 1.78sec±0.01; 1.79sec±0.01; 1.78sec ±0.03. The antibacterial activity test found that the hand antiseptic gel preparation of clove leaf ethanol extract had the ability to inhibitbacteria Staphylococcus aureus in the medium category with an inhibition zone of 8.88; 9.37 and 9.98 mm, with p-value <0.05, which means there is a significant difference in the concentration value..
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