UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAN FRAKSI n-HEKSAN,
ETIL ASETAT DAN AIR DARI SABUT KELAPA MUDA (Cocos nucifera
Linn) TERHADAP Escherichia coli ESBL (Extended Spectrum Beta
Lactamase)
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Novia, Dewi Purwaningrum
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2022-04-14 07:41:57
Abstract :
Young coconut coir contains flavonoid compounds, phenols, tannins and saponins that can be used as antibacterial. The ethanol extract of young coconut coir was studied to have good antibacterial activity. This study aimed to see the inhibitory activity of ethanol extract compared fractions of young coconut coir ethanol extract in inhibiting Escherichia coli ESBL (Extended Spectrum Beta Lactamase) bacteria. Young coconut coir of extracted using 95% ethanol solvent of maceration method and patition using n-hexane and ethyl acetate solvent. Antibacterial activities using the diffusion method with concentrations of 25%, 50% and 75%. The negative control used DMSO 10%, while positve control used was chloramphenikol. The result are shown from the radical inhibition zone diameter. Statistical analysis of antibacterial test results using One Way Anova Ethanol extract and fractions of ethanol extract of young coconut coir inhibited Escherichia coli ESBL bacteria. The largest radical inhibition zone was found in the ethyl acetate fraction with a concentration of 75% at 10.9 mm. Statistical analysis showed that the extract and fractions of young coconut coir ethanol extract were significantly different from the negative control (sig <0.05).
Young coconut coir contains flavonoid compounds, phenols, tannins and saponins that can be used as antibacterial. The ethanol extract of young coconut coir was studied to have good antibacterial activity. This study aimed to see the inhibitory activity of ethanol extract compared fractions of young coconut coir ethanol extract in inhibiting Escherichia coli ESBL (Extended Spectrum Beta Lactamase) bacteria. Young coconut coir of extracted using 95% ethanol solvent of maceration method and patition using n-hexane and ethyl acetate solvent. Antibacterial activities using the diffusion method with concentrations of 25%, 50% and 75%. The negative control used DMSO 10%, while positve control used was chloramphenikol. The result are shown from the radical inhibition zone diameter. Statistical analysis of antibacterial test results using One Way Anova Ethanol extract and fractions of ethanol extract of young coconut coir inhibited Escherichia coli ESBL bacteria. The largest radical inhibition zone was found in the ethyl acetate fraction with a concentration of 75% at 10.9 mm. Statistical analysis showed that the extract and fractions of young coconut coir ethanol extract were significantly different from the negative control (sig <0.05).
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