OPTIMASI PELARUT EKSTRAKSI DAUN RAMBUTAN (Nephelium
lappaceum L.) TERHADAP KADAR FLAVONOID TOTAL DAN
AKTIVITAS ANTIOKSIDAN DENGAN METODE SIMPLEX LATTICE
DESIGN
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Tarasia, Gandes Belani
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2022-04-14 07:42:28
Abstract :
The selection of the right combination of solvents can affect the abstracted compounds. Rambutan leaves contain flavonoid compounds that are useful as antioxidants. This study aims to know the optimal solvent combination in flavonoids so that total flavonoid levels and antioxidant activity are obtained and the influence of optimal solvent composition with total flavonoid levels and antioxidant activity of rambutan leaf extract (Nephelium lappaceum L.). Rambutan leaves extracted by maceration method using 8 solvent formulas further measured total flavonoid levels using the method of colorimetry and antioxidant activity using the ABTS method. Determination of optimal formula using the simplex lattice design method. The verification test is conducted using the SPPS One Sample T-Test. Analysis of the influence of optimal solvent composition with total flavonoid levels and antioxidant activity using pearson correlation. The results of the identification of the compound showed rambutan leaf extract contains flavonoid compounds, phenols, alkaloids and saponins. Obtained the composition of water solvent 0% and ethanol 100% in the optimal formula. The results of determining the total flavonoid levels and antiosidant activity of the optimal formula are 12.28 ± 0.062% QE, 12.25 ± 0.116 % QE, 12.20 ± 0.025 % QE and 7.14 ± 0.047 ppm, 7.07 ± 0.05 ppm, 7.17 ±0.02 ppm with statistical results of one sample t>0.05 and correlation coefficient -0.947
The selection of the right combination of solvents can affect the abstracted compounds. Rambutan leaves contain flavonoid compounds that are useful as antioxidants. This study aims to know the optimal solvent combination in flavonoids so that total flavonoid levels and antioxidant activity are obtained and the influence of optimal solvent composition with total flavonoid levels and antioxidant activity of rambutan leaf extract (Nephelium lappaceum L.). Rambutan leaves extracted by maceration method using 8 solvent formulas further measured total flavonoid levels using the method of colorimetry and antioxidant activity using the ABTS method. Determination of optimal formula using the simplex lattice design method. The verification test is conducted using the SPPS One Sample T-Test. Analysis of the influence of optimal solvent composition with total flavonoid levels and antioxidant activity using pearson correlation. The results of the identification of the compound showed rambutan leaf extract contains flavonoid compounds, phenols, alkaloids and saponins. Obtained the composition of water solvent 0% and ethanol 100% in the optimal formula. The results of determining the total flavonoid levels and antiosidant activity of the optimal formula are 12.28 ± 0.062% QE, 12.25 ± 0.116 % QE, 12.20 ± 0.025 % QE and 7.14 ± 0.047 ppm, 7.07 ± 0.05 ppm, 7.17 ±0.02 ppm with statistical results of one sample t>0.05 and correlation coefficient -0.947
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