FORMULASI GEL EKSTRAK DAUN PANDAN WANGI (Pandanus
amaryllifolius Roxb.) DENGAN BASIS HYDROXY PROPYL METHYL
CELLULOSE (HPMC) SEBAGAI ANTIBAKTERI TERHADAP
Staphylococcus aureus
Total View This Week0
Total View This Week0
Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Febriana, Eka Valentina
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2022-07-05 02:08:53
Abstract :
Pandan leaves (Pandanus amaryllifolius Roxb.) contain various compounds including flavonoid compounds, alkaloids, and saponins. Fragrant pandan leaves have potential antibacterial effectiveness. Antibacterial gel preparations are intended to kill pathogenic bacteria on the skin. The advantages of using a gel compared to other topical preparations are that the gel has high adhesion, does not interfere with breathing in the skin pores, is easily washed off in water, and absorbs the drug in the skin well. The purpose of this study was to determine at what concentration HPMC as a gelling agent was able to produce a gel extract of fragrant pandan leaves (Pandanus amaryllifolius Roxb.) which had good physical and antibacterial stability against Staphylococcus aureus gel and antibacterial activity against Staphylococcus aureus. This research includes the extraction of fragrant pandan leaves using the maceration method with 96% ethanol solvent. The pandan fragrant leaf extract gel was made in 3 formulas, with each formula having a different concentration of HPMC. Formula I with a concentration of 2%, formula II with a concentration of 3%, and formula III with a concentration of 4%. The gel that had been made was then tested for physical stability for 21 days on days 0, 7, 14, and 21 which included organoleptic test, homogeneity test, pH test, viscosity test, dispersibility test, adhesion test, and protection test. Antibacterial activity test using well method. The test data obtained were analyzed using One Way Anova. The results showed the best base concentration of HPMC 2% by organoleptic test (thick gel, blackish green color, characteristic pandan fragrance), homogeneous homogeneity, pH 6±0 which is safe on skin pH, viscosity of 325±0 dPas, dispersion of 7,5 g.cm/s, adhesion of 15,17±0.00 seconds, and antibacterial activity against Staphylococcus aureus with an inhibition zone of 27,26±25,30 mm which was included in the very strong category.
Pandan leaves (Pandanus amaryllifolius Roxb.) contain various compounds including flavonoid compounds, alkaloids, and saponins. Fragrant pandan leaves have potential antibacterial effectiveness. Antibacterial gel preparations are intended to kill pathogenic bacteria on the skin. The advantages of using a gel compared to other topical preparations are that the gel has high adhesion, does not interfere with breathing in the skin pores, is easily washed off in water, and absorbs the drug in the skin well. The purpose of this study was to determine at what concentration HPMC as a gelling agent was able to produce a gel extract of fragrant pandan leaves (Pandanus amaryllifolius Roxb.) which had good physical and antibacterial stability against Staphylococcus aureus gel and antibacterial activity against Staphylococcus aureus. This research includes the extraction of fragrant pandan leaves using the maceration method with 96% ethanol solvent. The pandan fragrant leaf extract gel was made in 3 formulas, with each formula having a different concentration of HPMC. Formula I with a concentration of 2%, formula II with a concentration of 3%, and formula III with a concentration of 4%. The gel that had been made was then tested for physical stability for 21 days on days 0, 7, 14, and 21 which included organoleptic test, homogeneity test, pH test, viscosity test, dispersibility test, adhesion test, and protection test. Antibacterial activity test using well method. The test data obtained were analyzed using One Way Anova. The results showed the best base concentration of HPMC 2% by organoleptic test (thick gel, blackish green color, characteristic pandan fragrance), homogeneous homogeneity, pH 6±0 which is safe on skin pH, viscosity of 325±0 dPas, dispersion of 7,5 g.cm/s, adhesion of 15,17±0.00 seconds, and antibacterial activity against Staphylococcus aureus with an inhibition zone of 27,26±25,30 mm which was included in the very strong category.
Download
book
BibTex
Latex, Jabref
cloud_download
Original Resource
url resource Institution
