FORMULASI DAN EVALUASI SEDIAAN NANOEMULSIEKSTRAK UMBI BAWANG PUTIH (AlliumsativumL.)
Total View This Week0
Total View This Week0
Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Alvira, Intan Widyastuti
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2022-07-05 02:08:55
Abstract :
Garlic bulbs (Allium sativum L.) have an active substance in the formof thermolabile allicin, allicin as the main antioxidant that can prevent free radicals. Nanoemulsion has a particle size of 20-500 nm which is an oil and water dispersionsystem which is stabilized by a combination of surfactants and cosurfactants. Thepurpose of this study was to obtain the best formula from variations inVCOconcentration of 3%, 5%, 8% and to determine the stability of the nanoemulsionpreparation. The nanoemulsion was formulated in the oil phase of VCO, surfactant Tween 80, and cosurfactant PEG 400. The nanoemulsion preparations were testedfor organoleptic, pH, viscosity, % transmittance, stability. The best formula wasfollowed by particle size and zeta potential tests, the results of the researchwereanalyzed by one way ANOVA test. The best formula was obtained for thepreparation of garlic bulb extract nanoemulsion at a concentration of 8%VCO, thebest physical formula was obtained with organoleptic characteristics of clear yellow, distinctive odor, and did not separate, pH value (4.9), viscosity value (7.0 d'Pas) , the value of % transmittance (96.11), the preparation of garlic bulb nanoemulsionwas stable after the stability test was carried out. The best formula was continuedwith the particle size test, the average value obtained (607.0±53.4) and the averagevalue of the zeta potential test obtained (-5.7±0.86). The preparationof nanoemulsion that has good stability is in formula 3 with a VCOconcentrationof 8%.
Garlic bulbs (Allium sativum L.) have an active substance in the formof thermolabile allicin, allicin as the main antioxidant that can prevent free radicals. Nanoemulsion has a particle size of 20-500 nm which is an oil and water dispersionsystem which is stabilized by a combination of surfactants and cosurfactants. Thepurpose of this study was to obtain the best formula from variations inVCOconcentration of 3%, 5%, 8% and to determine the stability of the nanoemulsionpreparation. The nanoemulsion was formulated in the oil phase of VCO, surfactant Tween 80, and cosurfactant PEG 400. The nanoemulsion preparations were testedfor organoleptic, pH, viscosity, % transmittance, stability. The best formula wasfollowed by particle size and zeta potential tests, the results of the researchwereanalyzed by one way ANOVA test. The best formula was obtained for thepreparation of garlic bulb extract nanoemulsion at a concentration of 8%VCO, thebest physical formula was obtained with organoleptic characteristics of clear yellow, distinctive odor, and did not separate, pH value (4.9), viscosity value (7.0 d'Pas) , the value of % transmittance (96.11), the preparation of garlic bulb nanoemulsionwas stable after the stability test was carried out. The best formula was continuedwith the particle size test, the average value obtained (607.0±53.4) and the averagevalue of the zeta potential test obtained (-5.7±0.86). The preparationof nanoemulsion that has good stability is in formula 3 with a VCOconcentrationof 8%.
Download
book
BibTex
Latex, Jabref
cloud_download
Original Resource
url resource Institution
