FORMULASI SEDIAAN TABLET EFFERVESCENT EKSTRAK
DAUN JERUK BALI (Citrus maxima (Burm.) Merr) SEBAGAI
DISINFEKTAN
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Amanda, Arinisa Putri
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2022-07-05 02:08:56
Abstract :
Disinfectants is a chemicals its used to detain of growth for microorganisms on the surface of inanimate objects. One of the natural ingridients which can used as a Disinfectants is bali lime leaf (citrus maxima) burm. Merr) contains the main compound, that is flavonoid which can detain the growth of the staphylococcus aureus bacteria. Bali lime leaf extraction formulated into effervescent tablet preparations that has the advantage of facilitating use with a measurable dose that when used can be directly dissolved in 1 liter of water per 1 tablet. The purpose of this study was to determine the influence of variations in the amount of Sodium bicarbonate FI (25%), FII (35%), and FIII (45%) on the physical quality of tablets made using wet granulation methods as well as the influence of sodium bicarbonate variations on the physical properties of effervescent tablets and the ability to inhibit the growth of Staphylococcus aureus bacteria using disc diffusion methods and analysis of results using the One-Way Anova Test on weight uniformity tests, uniformity of size, hardness of tablets, as well as S.areus bacterial inhibitory power tests and descriptive analysis on granule physical properties tests, organoleptic testt, friability test, hardness test, dissolving time test, and pH test. Formula 1 shows the most optimum results. With a water content of 2.46%, flow time 3,55 seconds, angle of repose 27,92°, weight uniformity 0,524 ±0,024 mg, uniformity of size 1,322 ± 0.004 ± cm, tablet friability 0,56%, tablet hardness 4,040 ± 1.577, dissolving time 3 minutes 15 seconds, and pH test 6.3. The difference of quality of natrium bikarbonat on effevescent tablet of bali lime leaf take effect on the difference in the area of the inhibition zone staphylococcus aureus bacteria with an average 11,20 1,322 ± 0,067 mm.
Disinfectants is a chemicals its used to detain of growth for microorganisms on the surface of inanimate objects. One of the natural ingridients which can used as a Disinfectants is bali lime leaf (citrus maxima) burm. Merr) contains the main compound, that is flavonoid which can detain the growth of the staphylococcus aureus bacteria. Bali lime leaf extraction formulated into effervescent tablet preparations that has the advantage of facilitating use with a measurable dose that when used can be directly dissolved in 1 liter of water per 1 tablet. The purpose of this study was to determine the influence of variations in the amount of Sodium bicarbonate FI (25%), FII (35%), and FIII (45%) on the physical quality of tablets made using wet granulation methods as well as the influence of sodium bicarbonate variations on the physical properties of effervescent tablets and the ability to inhibit the growth of Staphylococcus aureus bacteria using disc diffusion methods and analysis of results using the One-Way Anova Test on weight uniformity tests, uniformity of size, hardness of tablets, as well as S.areus bacterial inhibitory power tests and descriptive analysis on granule physical properties tests, organoleptic testt, friability test, hardness test, dissolving time test, and pH test. Formula 1 shows the most optimum results. With a water content of 2.46%, flow time 3,55 seconds, angle of repose 27,92°, weight uniformity 0,524 ±0,024 mg, uniformity of size 1,322 ± 0.004 ± cm, tablet friability 0,56%, tablet hardness 4,040 ± 1.577, dissolving time 3 minutes 15 seconds, and pH test 6.3. The difference of quality of natrium bikarbonat on effevescent tablet of bali lime leaf take effect on the difference in the area of the inhibition zone staphylococcus aureus bacteria with an average 11,20 1,322 ± 0,067 mm.
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