OPTIMASI FORMULA GEL EKSTRAK DAUN BELIMBING
WULUH (Averrhoa bilimbi L.) DENGAN VARIASI
CARBOXYMETHYLCELLULOSE SODIUM (CMC-NA) DAN
CARBOPOL 940 DAN UJI AKTIVITAS TERHADAP BAKTERI
Staphylococcus aureus
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Pingki, Retnosari
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2022-07-05 02:09:30
Abstract :
Starfruit leaves are one of the plants that have antibacterial properties. Flavonoids in star fruit leaves can function as antibacterial against Staphylococcus aureus, in a concentration of 10% has a strong inhibitory power. Gel preparations have several advantages including water content that is cooling, soothing, moisturizing, easy to use, easy to penetrate the skin, thus providing a healing effect. The purpose of this study was to determine the optimal ratio of CMC-Na and carbopol 940 in the leaf extract gel of Averrhoa bilimbi Linn starfruit leaf extract using the Simplex lattice design (SLD) method and to determine the antibacterial activity against Staphylococcus aureus. Extraction of star fruit leaves by maceration extraction method using 96% ethanol. Determination of the optimal formula using the Simplex Lattice Design method using Design Expert 11. Verify the optimal formula with a one sample T-test. Antibacterial activity test against Staphylococcus aureus by well method and the results were analyzed by One Way Anova. The optimal concentrations of CMC-Na and carbopol 940 produced by the Simplex Lattice Design method were CMC-Na of 35% (0.7 g) and Carbopol 940 of 65% (1.3 g) with a total weight of 2g basis. The results of the antibacterial test showed that the gel preparation was able to inhibit Staphylococcus aureus bacteria with an average inhibition zone of 14.43±0.707. The results of the optimal formula verification test obtained p value> 0.05 so that the data obtained were not significantly different and it can be said that the formula for the results of the simplex lattice design method was valid as expected including pH, viscosity, spreadability, adhesion.
Starfruit leaves are one of the plants that have antibacterial properties. Flavonoids in star fruit leaves can function as antibacterial against Staphylococcus aureus, in a concentration of 10% has a strong inhibitory power. Gel preparations have several advantages including water content that is cooling, soothing, moisturizing, easy to use, easy to penetrate the skin, thus providing a healing effect. The purpose of this study was to determine the optimal ratio of CMC-Na and carbopol 940 in the leaf extract gel of Averrhoa bilimbi Linn starfruit leaf extract using the Simplex lattice design (SLD) method and to determine the antibacterial activity against Staphylococcus aureus. Extraction of star fruit leaves by maceration extraction method using 96% ethanol. Determination of the optimal formula using the Simplex Lattice Design method using Design Expert 11. Verify the optimal formula with a one sample T-test. Antibacterial activity test against Staphylococcus aureus by well method and the results were analyzed by One Way Anova. The optimal concentrations of CMC-Na and carbopol 940 produced by the Simplex Lattice Design method were CMC-Na of 35% (0.7 g) and Carbopol 940 of 65% (1.3 g) with a total weight of 2g basis. The results of the antibacterial test showed that the gel preparation was able to inhibit Staphylococcus aureus bacteria with an average inhibition zone of 14.43±0.707. The results of the optimal formula verification test obtained p value> 0.05 so that the data obtained were not significantly different and it can be said that the formula for the results of the simplex lattice design method was valid as expected including pH, viscosity, spreadability, adhesion.
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