UJI TOKSISITAS AKUT EKSTRAK ETANOL 70% BAWANG
LANANG HITAM (Allium sativum L) PADA MENCIT PUTIH
JANTAN
Total View This Week0
Total View This Week0
Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Rizka, Apri Utami
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2022-07-05 02:09:46
Abstract :
Indonesia is a tropical country with potential plants that are empirically used as traditional medicine. One of them is black garlic which is fermented garlic at a temperature of 40-80°C with a relative humidity of 70-80% for 15 days. Empirically garlic is used as a medicine for various diseases, such as warts, hypertension, heart disease, cancer, diabetes. This study aims to determine the acute toxicity of black garlic which can cause 50% death as measured by the LD50 value (lethal dose 50%) in male white mice. Black onion extract was obtained by maceration using 70% ethanol. Acute toxicity test was carried out by giving treatment to each group, namely Group I as a normal control who was given CMC-Na 0.5%, Group II was treated with ethanol extract of black onion at a dose of 2000mg/KgBB, Group III was given treatment with ethanol extract of black onion at a dose of 2500mg/KgBB, and group IV was given treatment with ethanolic extract of Black Lanang at a dose of 3000mg/KgBB. Phytochemical screening showed that the ethanolic extract of black onion was positive for flavonoids, saponins, polyphenols, and alkaloids. The results obtained in this study were that there were no deaths of test animals in all groups, but there were toxicity symptoms, namely soft stools/diarrhea, passive mouse activity, tremors, hair did not fall out, and weight gain.
Indonesia is a tropical country with potential plants that are empirically used as traditional medicine. One of them is black garlic which is fermented garlic at a temperature of 40-80°C with a relative humidity of 70-80% for 15 days. Empirically garlic is used as a medicine for various diseases, such as warts, hypertension, heart disease, cancer, diabetes. This study aims to determine the acute toxicity of black garlic which can cause 50% death as measured by the LD50 value (lethal dose 50%) in male white mice. Black onion extract was obtained by maceration using 70% ethanol. Acute toxicity test was carried out by giving treatment to each group, namely Group I as a normal control who was given CMC-Na 0.5%, Group II was treated with ethanol extract of black onion at a dose of 2000mg/KgBB, Group III was given treatment with ethanol extract of black onion at a dose of 2500mg/KgBB, and group IV was given treatment with ethanolic extract of Black Lanang at a dose of 3000mg/KgBB. Phytochemical screening showed that the ethanolic extract of black onion was positive for flavonoids, saponins, polyphenols, and alkaloids. The results obtained in this study were that there were no deaths of test animals in all groups, but there were toxicity symptoms, namely soft stools/diarrhea, passive mouse activity, tremors, hair did not fall out, and weight gain.
Download
book
BibTex
Latex, Jabref
cloud_download
Original Resource
url resource Institution
