UJI TOKSISITAS AKUT FRAKSI N-HEKSAN KORO
BENGUK (Mucuna pruriens L.) PADA MENCIT PUTIH
JANTAN
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Syafa, Nur Oktaviani
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2022-07-05 02:09:48
Abstract :
Koro Benguk is a tropical plant that is widely available throughout Indonesia, but its use is still limited. The uses of this plant include antibacterial, gout, cancer, diabetes, kidney stones, and others, so it is necessary to do research on the level of safety. The purpose of this study was to calculate the LD50 value of the compound that could be detected within 24 hours after being given a single dose. The n-hexane fraction was administered orally to mice where there were 4 groups, namely group 1 given CMC-Na as a control, group II at a dose of 2000 mg/kgBW, group III 2500 mg/KgBW and group IV 3200 mg/KgBW. The results showed that the n-hexane fraction of koro benguk (Mucuna pruriens L.) caused a toxic effect at a dose of 2500 mg/KgBW and at a dose of 3200 mg/KgBW, 1 test animal died. The results of the calculation of LD50 is 3688.077 mg/kg BW including moderate toxic category with symptoms that arise, namely mice become passive, and diarrhea.
Koro Benguk is a tropical plant that is widely available throughout Indonesia, but its use is still limited. The uses of this plant include antibacterial, gout, cancer, diabetes, kidney stones, and others, so it is necessary to do research on the level of safety. The purpose of this study was to calculate the LD50 value of the compound that could be detected within 24 hours after being given a single dose. The n-hexane fraction was administered orally to mice where there were 4 groups, namely group 1 given CMC-Na as a control, group II at a dose of 2000 mg/kgBW, group III 2500 mg/KgBW and group IV 3200 mg/KgBW. The results showed that the n-hexane fraction of koro benguk (Mucuna pruriens L.) caused a toxic effect at a dose of 2500 mg/KgBW and at a dose of 3200 mg/KgBW, 1 test animal died. The results of the calculation of LD50 is 3688.077 mg/kg BW including moderate toxic category with symptoms that arise, namely mice become passive, and diarrhea.
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