FORMULASI TABLET EFFERVESCENT DARI EKSTRAK
SIRIH CINA (Peperomia Pellucida L.) SEBAGAI DISINFEKTAN
ALAMI
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Vinsensia, Ivana Widjayanti
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2022-07-05 02:10:13
Abstract :
Chinese Betel herb (Peperomia pellucida L.) has flavonoid and saponin content compounds that can inhibit bacterial growth. Disinfectant effervescent tablets are a new innovation in Indonesia because this preparation is not much on the market, besides that the advantages of this effervescent tablet can make it easier for us to make disinfectants. Chinese betel herb extract is formulated into an effervescent tablet preparation. This study aims to determine the influence of variations in the levels of binders and fillers on the physical properties of effervescent tablet preparations and find out the activity of the effervescent tablet formula of Chinese betel extract (Peperomia pellucida L.) in inhibiting the growth of Staphylococcus aureus bacteria. Chinese betel herb extract is obtained through a maceration extraction process using methanol solvent for 5 days. The preparation of effervescent tablets is made 3 formulas, namely the concentration of binding substances 10%, 13%, 15%. Physical tests of tablet preparations include organoleptic tests, size uniformity tests, tablet hardness tests, tablet soluble time tests, weight uniformity tests, fragility tests and antibacterial activity tests against Staphylococcus aureus with disc paper diffusion methods. The best formula tablets are formula I (PEG 10%) with uniformity of weight 525±17,014, tablet hardness 3,452±1,172, tablet fragility 0.264%, soluble time 1 minute 6 seconds, uniformity size 3.33±0.06. The results of antibacterial activity tests showed weak inhibitory power with an average formula value of 4.51±0.02.
Chinese Betel herb (Peperomia pellucida L.) has flavonoid and saponin content compounds that can inhibit bacterial growth. Disinfectant effervescent tablets are a new innovation in Indonesia because this preparation is not much on the market, besides that the advantages of this effervescent tablet can make it easier for us to make disinfectants. Chinese betel herb extract is formulated into an effervescent tablet preparation. This study aims to determine the influence of variations in the levels of binders and fillers on the physical properties of effervescent tablet preparations and find out the activity of the effervescent tablet formula of Chinese betel extract (Peperomia pellucida L.) in inhibiting the growth of Staphylococcus aureus bacteria. Chinese betel herb extract is obtained through a maceration extraction process using methanol solvent for 5 days. The preparation of effervescent tablets is made 3 formulas, namely the concentration of binding substances 10%, 13%, 15%. Physical tests of tablet preparations include organoleptic tests, size uniformity tests, tablet hardness tests, tablet soluble time tests, weight uniformity tests, fragility tests and antibacterial activity tests against Staphylococcus aureus with disc paper diffusion methods. The best formula tablets are formula I (PEG 10%) with uniformity of weight 525±17,014, tablet hardness 3,452±1,172, tablet fragility 0.264%, soluble time 1 minute 6 seconds, uniformity size 3.33±0.06. The results of antibacterial activity tests showed weak inhibitory power with an average formula value of 4.51±0.02.
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