EVALUASI REKONSTITUSI INJEKSI SEFTRIAKSON DI
RUMAH SAKIT UMUM MOJOSONGO 2 KARANGANYAR
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Wida, Wahyu Utami
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2022-07-05 02:10:53
Abstract :
Ceftriaxone injection is a third-generation cephalosporin broadspectrum antibiotic, which in its use in hospitals requires a compounding process, namely reconstitution and dilution. In accordance with applicable regulations and guidelines, the compounding of sterile preparations must be carried out with appropriate facilities, an aseptic compounding process, and carried out by pharmaceutical personnel, in order to obtain preparations with good quality and stability. This study aims to observe the compounding process and physical properties of the compounding of ceftriaxone injection preparations carried out at one of the Mojosongo 2 General Hospital Karanganyar in the period December 2021 -January 2022. The research was conducted by observation of compounding personnel, and the process of compounding ceftriaxone injection preparations. Observations were carried out with the help of a check list that was adjusted to the Standard Operating Procedure (SOP) at Mojosongo 2 General Hospital Karanganyar. A total of 32 ceftriaxone injection compounding processes were used as samples. The results of compounding with process conditions are not in accordance with standard operating procedures (SOP) are 0,8 % SOP at the mixing stage. The results showed that the compounding of ceftriaxone injection preparations at Mojosongo 2 General Hospital, Karanganyar was 99.2% in accordance with the applicable Standard Operating Procedures (SOP).
Ceftriaxone injection is a third-generation cephalosporin broadspectrum antibiotic, which in its use in hospitals requires a compounding process, namely reconstitution and dilution. In accordance with applicable regulations and guidelines, the compounding of sterile preparations must be carried out with appropriate facilities, an aseptic compounding process, and carried out by pharmaceutical personnel, in order to obtain preparations with good quality and stability. This study aims to observe the compounding process and physical properties of the compounding of ceftriaxone injection preparations carried out at one of the Mojosongo 2 General Hospital Karanganyar in the period December 2021 -January 2022. The research was conducted by observation of compounding personnel, and the process of compounding ceftriaxone injection preparations. Observations were carried out with the help of a check list that was adjusted to the Standard Operating Procedure (SOP) at Mojosongo 2 General Hospital Karanganyar. A total of 32 ceftriaxone injection compounding processes were used as samples. The results of compounding with process conditions are not in accordance with standard operating procedures (SOP) are 0,8 % SOP at the mixing stage. The results showed that the compounding of ceftriaxone injection preparations at Mojosongo 2 General Hospital, Karanganyar was 99.2% in accordance with the applicable Standard Operating Procedures (SOP).
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