OPTIMASI FORMULA SELF-NANOEMULSIFYING DRUG
DELIVERY SYSTEM (SNEDDS) FRAKSI ETIL ASETAT DAUN
SIRSAK (Annona muricata L.) DENGAN METODE SIMPLEX
LATTICE DESIGN
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Yulia, Ratna Karunia Wati
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2022-07-05 02:11:04
Abstract :
Cancer is a disease that is not foreign to the public. Soursop leaves have annonaceous acetogenins compounds that can form naturally in soursop plants, and are more specific to attack cancer cells in the body without affecting normal cells in the body, especially cervical cancer cells. At what concentration can a good SNEDDS formula be formed? In the formulation process, it is necessary to optimize the preparation to determine which formula can be obtained using the help of data from the evaluation results from preparations that have been made previously. The data analysis used in this study was to obtain a formula using the Simplex lattice design in the Design expert software 13.0 and then verified using the one sample t-test. as many as 14 runs and tested for % transmittance and emulsion time as the influence factor for making the optimal formula. and obtained the optimum formula with a desirability value of 0.769. Formula verification was carried out using one sample t-test, the optimal formula was tested for particle size. The average particle size obtained from the optimal formula was 13.83 nm ± 0.650, the polydispersity index in the formula was 0.143 ± 0.128 (0.5) range acceptable polydispersity index is 0-0.5. The results of the zeta potential test carried out on the ethyl acetate fraction SNEDDS formula were -0.23 Mv ± 0.057. The concentration of components of VCO oil (0.56 ml), Surfactant (3.50 ml), and Propylene glycol (0.93 ml) in the SNEDDS formula was able to produce optimal and homogeneous preparations, the formula produced from the Simplex Lattice Design method had a derirability value of 0.769 . The optimal SNEDDS formula produced met the criteria for a good SNEDDS formula at an emulsification time of 53 seconds, a % transmittance value of 96.3%, a particle size of 13.8 nm ± 0.650 and a zeta potential value of -0.23 Mv ± 0.057.
Cancer is a disease that is not foreign to the public. Soursop leaves have annonaceous acetogenins compounds that can form naturally in soursop plants, and are more specific to attack cancer cells in the body without affecting normal cells in the body, especially cervical cancer cells. At what concentration can a good SNEDDS formula be formed? In the formulation process, it is necessary to optimize the preparation to determine which formula can be obtained using the help of data from the evaluation results from preparations that have been made previously. The data analysis used in this study was to obtain a formula using the Simplex lattice design in the Design expert software 13.0 and then verified using the one sample t-test. as many as 14 runs and tested for % transmittance and emulsion time as the influence factor for making the optimal formula. and obtained the optimum formula with a desirability value of 0.769. Formula verification was carried out using one sample t-test, the optimal formula was tested for particle size. The average particle size obtained from the optimal formula was 13.83 nm ± 0.650, the polydispersity index in the formula was 0.143 ± 0.128 (0.5) range acceptable polydispersity index is 0-0.5. The results of the zeta potential test carried out on the ethyl acetate fraction SNEDDS formula were -0.23 Mv ± 0.057. The concentration of components of VCO oil (0.56 ml), Surfactant (3.50 ml), and Propylene glycol (0.93 ml) in the SNEDDS formula was able to produce optimal and homogeneous preparations, the formula produced from the Simplex Lattice Design method had a derirability value of 0.769 . The optimal SNEDDS formula produced met the criteria for a good SNEDDS formula at an emulsification time of 53 seconds, a % transmittance value of 96.3%, a particle size of 13.8 nm ± 0.650 and a zeta potential value of -0.23 Mv ± 0.057.
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