Uji Antibakteri dan Antioksidan dari Ekstrak Metanol Daun dan Kulit Batang Nangka sebagai Campuran Masker
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Institusion
Universitas Sumatera Utara
Author
Siregar, Ahmad Budiman
Subject
Antibacterial
Datestamp
2018-12-18 03:23:33
Abstract :
Antibacterial and antioxidant test have been conducted using methanol extract of leave and stem bark of Artocarpus for its application as peel-off mask. The raw material was macerated using methanol and the obtained filtrate was evaporated until the concentrated crude extract was obtained. The crude extract is tested using several tests, such a phytochemistry screening, antibacterial test to Propionibakterium acnes and Staphylococcus aureus with the concentration of extract of 50; 100; 150 and 200 ppm, and antioxidant test using DPPH method. The additional test was conducted for evaluating the characteristic of peel-off mask, such as homogeneity, pH, organoleptic and irritation test. The result of photochemistry screening showed those extracts were dominated with tannin and saponin. The antibacterial test to P. acnes showed the leave extract with concentration of 50, 100, 150 and 200 ppm showed the inhibition zone 9,6; 9,9; 10,4 and 11,3 mm. The other extract, the stem bark extract, provided the inhibition zone 8,4; 8,8; 9,5 and 10,5 mm at the similar concentraion of extract. For Staphyliococcus aureus, the leaves extract showed the inhibition zone 7,5; 7,8; 8,2 and 8,8 mm, while the stem bark extract 6,2; 6,4; 7,7 dan 9,2 mm. Those result revealed that the leave extract is more powerful to inhibit P. acnes than stem bark extract. But the different result was obtained when discussed about the inhibition of S. aureus, the stem bark extract showed the higher activity than leave extract. The measurement of antioxidant of leave extract at concentration 50; 100; 150 and 200 ppm showed the following activity data 22,91; 31,90; 32,76 and 40,47%, then the stem bark extract has the followong activity data 43,89; 64,66; 70,02; 70,44%. These data showed the antioxidant activity of stem bark extract is higher than stem bark extract. The clinical testing of peel-off mask formulation showed that the FDN1, FDN2 and FDN3 has a good homogeneity and the pH was 6,7; 6,7 and 5,8. The irritation test showed a negative reasult for all of formulation.
Antibacterial and antioxidant test have been conducted using methanol extract of leave and stem bark of Artocarpus for its application as peel-off mask. The raw material was macerated using methanol and the obtained filtrate was evaporated until the concentrated crude extract was obtained. The crude extract is tested using several tests, such a phytochemistry screening, antibacterial test to Propionibakterium acnes and Staphylococcus aureus with the concentration of extract of 50; 100; 150 and 200 ppm, and antioxidant test using DPPH method. The additional test was conducted for evaluating the characteristic of peel-off mask, such as homogeneity, pH, organoleptic and irritation test. The result of photochemistry screening showed those extracts were dominated with tannin and saponin. The antibacterial test to P. acnes showed the leave extract with concentration of 50, 100, 150 and 200 ppm showed the inhibition zone 9,6; 9,9; 10,4 and 11,3 mm. The other extract, the stem bark extract, provided the inhibition zone 8,4; 8,8; 9,5 and 10,5 mm at the similar concentraion of extract. For Staphyliococcus aureus, the leaves extract showed the inhibition zone 7,5; 7,8; 8,2 and 8,8 mm, while the stem bark extract 6,2; 6,4; 7,7 dan 9,2 mm. Those result revealed that the leave extract is more powerful to inhibit P. acnes than stem bark extract. But the different result was obtained when discussed about the inhibition of S. aureus, the stem bark extract showed the higher activity than leave extract. The measurement of antioxidant of leave extract at concentration 50; 100; 150 and 200 ppm showed the following activity data 22,91; 31,90; 32,76 and 40,47%, then the stem bark extract has the followong activity data 43,89; 64,66; 70,02; 70,44%. These data showed the antioxidant activity of stem bark extract is higher than stem bark extract. The clinical testing of peel-off mask formulation showed that the FDN1, FDN2 and FDN3 has a good homogeneity and the pH was 6,7; 6,7 and 5,8. The irritation test showed a negative reasult for all of formulation.
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