Efektifitas Pemberian Ekstrak Etanol Daun Haramounting (Rhodomyrtus tomentosa (Aiton) Hassk.) sebagai Antioksidan dalam Melindungi Kerusakan Hati Mencit (Mus musculus L.) setelah Dipaparkan Asap Rokok Elektrik
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Institusion

Universitas Sumatera Utara

Author

Tanjung, Rendra Syahputra

Subject

Electric Cigarettes 

Datestamp

2018-12-18 04:59:06 

Abstract :
This study aims to find out the effectiveness of the Haramonting extract (Rhodomyrtus tomentosa (Aiton) Hassk.) in providing a protective effect on the liver for morfology, histology liver and liver function (SGPT and SGOT) of mice (Mus musculus L.) after being exposed to electric cigarette smoke. The design of this study used Completely Randomized Design (CRD) consisting of Positive Group, Negative Group and three treatments of Haramounting Leaf Ethanol Extract (Rhodomyrtus tomentosa (Aiton) Hassk.) for 30 days at a dose of 100 mg/KgBB, 200 mg/KgBB and 300 mg/KgBB for treament use of five replications. Liver organ preparations were made using paraffin block method and Hematoxylin Erlich-Eosin (HE) staining. Morphological observation of liver show signficant increase on liver weight (p<0,05) on treament postivite group. Histological observations of liver and liver function (SGPT and SGOT) showed that there were significant differences (p<0.05) between the average number of damaged cells and liver function of SGPT and SGOT in male mice that had been given Haramounting ethanol leaf extract of (Rhodomyrtus tomentosa (Aiton) Hassk.) after being exposed to electric cigarette smoke on treatment dose of 100mg/KgBB. Giving haramounting leaf ethanol extract as an antioxidant after exposure to electric cigarette smoke can effectively regenerate damaged liver cells.