Kadar Protein C, Protein S, dan Antitrombin III pada Pasien Stroke Iskemik Akut di Rumah Sakit Umum Pusat Haji Adam Malik Medan
Total View This Week0
Total View This Week0
Institusion
Universitas Sumatera Utara
Author
Muchti, Jenie Erawati
Subject
Acute Ischemic Stroke
Datestamp
2018-12-19 06:53:00
Abstract :
Background Ischemic stroke is a clinical syndrome with rapidly develop loss of brain function due to disturbance in the blood supply to the brain, due to ischemia (lack of glucose and oxygen supply) caused by thrombosis or embolism. The role of natural anticoagulants Protein C, Protein S and Antithrombin III in ischemic stroke is still not widely known. It is important to look at the levels of Protein C, Protein S and Antithrombin III before the occurrence of ischemic stroke. The purpose of this study was to determine differences in levels of protein C, Protein S and Antithrombin III which were examined on days 1, 3 and 7 in acute ischemic stroke during treatment. Method This study was a longitudinal prospective method carried out in H. Adam Malik General Hospital Medan, from January to May 2018 in 21 acute ischemic stroke patients with three times of sampling, namely on day 1, 3 and 7. Examination of Protein C, Protein S and Antithrombin III uses a Coatron A4 device, Protein C and Antithrombin III with chromogenic assay principles and Protein S with clotting assay principles. Results 21 Patients who participated in the study were 12 men (57.1%), 9 women (42.9%). The results of Repeated Anova test and Friedman test found no significant differences on days 1, 3 and 7 for Protein C, Protein S and Antitrombin III. Correlation test between each Protein C, Protein S and Antithrombin III was positively and significantly correlated, while the correlation test of Protein C with Protein S had a no significant positive correlation, Protein C with Antithrombin III had no significant negative correlation, Protein S with Antithrombin III had no significant. Conclusion Average levels of Protein C, Protein S and Antithrombin III according to statistical results there is no significant differences on days 1, 3 7. It is recommended that samples be taken for a longer periode of time.
Background Ischemic stroke is a clinical syndrome with rapidly develop loss of brain function due to disturbance in the blood supply to the brain, due to ischemia (lack of glucose and oxygen supply) caused by thrombosis or embolism. The role of natural anticoagulants Protein C, Protein S and Antithrombin III in ischemic stroke is still not widely known. It is important to look at the levels of Protein C, Protein S and Antithrombin III before the occurrence of ischemic stroke. The purpose of this study was to determine differences in levels of protein C, Protein S and Antithrombin III which were examined on days 1, 3 and 7 in acute ischemic stroke during treatment. Method This study was a longitudinal prospective method carried out in H. Adam Malik General Hospital Medan, from January to May 2018 in 21 acute ischemic stroke patients with three times of sampling, namely on day 1, 3 and 7. Examination of Protein C, Protein S and Antithrombin III uses a Coatron A4 device, Protein C and Antithrombin III with chromogenic assay principles and Protein S with clotting assay principles. Results 21 Patients who participated in the study were 12 men (57.1%), 9 women (42.9%). The results of Repeated Anova test and Friedman test found no significant differences on days 1, 3 and 7 for Protein C, Protein S and Antitrombin III. Correlation test between each Protein C, Protein S and Antithrombin III was positively and significantly correlated, while the correlation test of Protein C with Protein S had a no significant positive correlation, Protein C with Antithrombin III had no significant negative correlation, Protein S with Antithrombin III had no significant. Conclusion Average levels of Protein C, Protein S and Antithrombin III according to statistical results there is no significant differences on days 1, 3 7. It is recommended that samples be taken for a longer periode of time.
Download
book
BibTex
Latex, Jabref
cloud_download
Original Resource
url resource Institution
