KADAR IL-12 DAN IL-22 PADA IBU HAMIL DENGAN KARIES GIGI
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Institusion
Universitas Airlangga
Author
GHINA ANJANI FAIZAHRIZQITHA, 021511133088
Subject
RK1-715 Dentistry
Datestamp
2019-04-04 06:20:16
Abstract :
Background: Dental caries is a pathologic process depends on several etiologic factors, which cause destruction of the dental tissues and produces local and general complications. The presence of dental caries in pregnant women could be used to identify dental caries in infants. The first changes that occurs during pregnancy is hormonal changes that will affect the composition of the microbium and cytokines, where in the oral cavity increases the pathogenic bacterium P. Gingivalis, A. Actinomycetemcomitans, as well as a slight increase in Streptococcus Mutans. In dental caries which already reached periapical will cause a high concentration of IL-12 and IL-22. Purpose: The purpose of this study was to determined the rate of IL-12 and IL-22 on pregnant women with dental caries. Method: A cross-sectional study of 20 pregnant women at Bhayangkara Hospital Surabaya by doing screening of dental caries and questionnaires to support the data, afterwards saliva sample were collected. Dental caries was then divided into two groups, low and high level of dental caries and saliva was tested by ELISA to occur the rate of IL-12 and IL-22. Result: The result of the study with Mann- Whitney Test obtained p=0,518 (p>0,05) for the correlation IL-12 in pregnant women to low and high level of dental caries, while for the correlation IL-22 in pregnant women to low and high level of dental caries was obtained p=0,068 (p>0,05). Conclusion: There was no increases of Interleukin-12 and Interleukin- 22 on pregnant women with higher level of dental caries
Background: Dental caries is a pathologic process depends on several etiologic factors, which cause destruction of the dental tissues and produces local and general complications. The presence of dental caries in pregnant women could be used to identify dental caries in infants. The first changes that occurs during pregnancy is hormonal changes that will affect the composition of the microbium and cytokines, where in the oral cavity increases the pathogenic bacterium P. Gingivalis, A. Actinomycetemcomitans, as well as a slight increase in Streptococcus Mutans. In dental caries which already reached periapical will cause a high concentration of IL-12 and IL-22. Purpose: The purpose of this study was to determined the rate of IL-12 and IL-22 on pregnant women with dental caries. Method: A cross-sectional study of 20 pregnant women at Bhayangkara Hospital Surabaya by doing screening of dental caries and questionnaires to support the data, afterwards saliva sample were collected. Dental caries was then divided into two groups, low and high level of dental caries and saliva was tested by ELISA to occur the rate of IL-12 and IL-22. Result: The result of the study with Mann- Whitney Test obtained p=0,518 (p>0,05) for the correlation IL-12 in pregnant women to low and high level of dental caries, while for the correlation IL-22 in pregnant women to low and high level of dental caries was obtained p=0,068 (p>0,05). Conclusion: There was no increases of Interleukin-12 and Interleukin- 22 on pregnant women with higher level of dental caries
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