Pengaruh Pemberian Ekstrak Kulit Pisang Mas (Musa acuminata Colla) Terhadap Kadar Kolesterol Total, LDL, Dan HDL Mencit Jantan Galur BALB-C Yang Hiperkolesterol
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Institusion
Universitas Kadiri
Author
Inawati, Yuni
Subject
RS Pharmacy and materia medica
Datestamp
2022-06-20 03:47:21
Abstract :
Hypercholesterolemia is a condition in which high cholesterol levels in blood plasma can increase the risk of atheroclerosis which can lead to coronary heart disease. Banana peel is one part of the plant that has anti-cholesterol activity. This research is an experimental test using 25 mice divided into 5 groups, namely positive control, negative control, and the treatment group with doses of 50mg / 20gBB mice, 100mg / 20gBB mice and 150mg / 20gBB mice. Blood was drawn 3 times through the orbital sinur vein on day 0, day 15 and day 29 to measure the total cholesterol, HDL and LDL levels of blood serum of mice using a Photometer Biolazer 100 with a wavelength of 546 nm. The data were processed using the SPSS application. Total cholesterol, HDL, and LDL cholesterol levels for the normality test (Shapiro Wilk) were declared normal (p> 0.05) and the homogeneity test (levene) was declared homogeneous (p> 0.05). The data were then analyzed using the One Way Anova test. Based on the results of the study, it was concluded that giving mas banana peel extract significantly affected total cholesterol levels and did not significantly affect HDL and LDL levels of mice. The dose of banana peel extract (Musa accuminata Colla) which is the most effective in affecting the total cholesterol level of hypercholesterolemic mice is the dose of 150 mg / 20gBB mice. Keywords : Hipercholesterolemia ; Banana peel (Musa accuminata Colla) extract; Total cholesterol, HDL, and LDL levels.
Hypercholesterolemia is a condition in which high cholesterol levels in blood plasma can increase the risk of atheroclerosis which can lead to coronary heart disease. Banana peel is one part of the plant that has anti-cholesterol activity. This research is an experimental test using 25 mice divided into 5 groups, namely positive control, negative control, and the treatment group with doses of 50mg / 20gBB mice, 100mg / 20gBB mice and 150mg / 20gBB mice. Blood was drawn 3 times through the orbital sinur vein on day 0, day 15 and day 29 to measure the total cholesterol, HDL and LDL levels of blood serum of mice using a Photometer Biolazer 100 with a wavelength of 546 nm. The data were processed using the SPSS application. Total cholesterol, HDL, and LDL cholesterol levels for the normality test (Shapiro Wilk) were declared normal (p> 0.05) and the homogeneity test (levene) was declared homogeneous (p> 0.05). The data were then analyzed using the One Way Anova test. Based on the results of the study, it was concluded that giving mas banana peel extract significantly affected total cholesterol levels and did not significantly affect HDL and LDL levels of mice. The dose of banana peel extract (Musa accuminata Colla) which is the most effective in affecting the total cholesterol level of hypercholesterolemic mice is the dose of 150 mg / 20gBB mice. Keywords : Hipercholesterolemia ; Banana peel (Musa accuminata Colla) extract; Total cholesterol, HDL, and LDL levels.
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