UJI EFEK ANTIDIABETIK FRAKSI ETIL ASETAT DAUN KENIKIR (Cosmos caudatus K.) PADA TIKUS JANTAN GALUR WISTAR YANG DIINDUKSI ALOKSAN
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Institusion
Sekolah Tinggi Ilmu Kesehatan Nasional
Author
Samuel, Axel Tanjung
Subject
RN Pharmacy and Pharmaceutical Mathematics
Datestamp
2020-12-23 02:50:32
Abstract :
High levels of glucose in the body to be a factor increasing free radicals. Treatment of diabetic can be treated with antioxidants. The test 2nd type antidiabetic effects of ethyl acetate fraction of kenikir (Cosmos caudatus K.) in male rats wistar strain induced by alloxan 150 mg / KgBW. This research is an experimental research design with pre and post test randomized controlled group design. Animal testing as much as 30 male rats were divided into 6 groups: normal group, negative control, positive control, a dose of 281.25 mg / kgBW; 562.5 mg / kgBW; and 1125 mg / kgBW ethyl acetate fraction of kenikir. All Group of test animals, except the normal group alloxan induced on day 0, followed by treatment of test animals from day 1 to day 14. Data obtained in the form of blood sugar levels in serum were taken on days 0, 7, and 14 and measured using the GOD-PAP. The data obtained were tested using ANOVA (Analysis of Variance) with (? = 0.05) continued Post Hoc Test (LSD). Ethyl acetate fraction of kenikir can lower blood sugar levels in diabetes mellitus 2nd type. Dose 281.25 mg / kgBW provide optimal effects with hypoglycemic percentages of 18.11%.
High levels of glucose in the body to be a factor increasing free radicals. Treatment of diabetic can be treated with antioxidants. The test 2nd type antidiabetic effects of ethyl acetate fraction of kenikir (Cosmos caudatus K.) in male rats wistar strain induced by alloxan 150 mg / KgBW. This research is an experimental research design with pre and post test randomized controlled group design. Animal testing as much as 30 male rats were divided into 6 groups: normal group, negative control, positive control, a dose of 281.25 mg / kgBW; 562.5 mg / kgBW; and 1125 mg / kgBW ethyl acetate fraction of kenikir. All Group of test animals, except the normal group alloxan induced on day 0, followed by treatment of test animals from day 1 to day 14. Data obtained in the form of blood sugar levels in serum were taken on days 0, 7, and 14 and measured using the GOD-PAP. The data obtained were tested using ANOVA (Analysis of Variance) with (? = 0.05) continued Post Hoc Test (LSD). Ethyl acetate fraction of kenikir can lower blood sugar levels in diabetes mellitus 2nd type. Dose 281.25 mg / kgBW provide optimal effects with hypoglycemic percentages of 18.11%.
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